{"id":"W2192368090","doi":"10.1016/j.jhep.2015.10.002","title":"Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice","year":2015,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias; Comisión Nacional de Investigación Científica y Tecnológica","keywords":"Genetically modified mouse; Transgene; Cholesterol; Chemistry; Cell biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004900657,0.001028945,0.0007180971,0.002005602,0.0006545132,0.0009553118,0.0005438723,0.001480581,0.003145486],"category_scores_gemma":[0.0004061946,0.0008407211,0.0009767221,0.0007076558,0.00104157,0.0006551461,0.0005697569,0.002002274,0.001319211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009517572,"about_ca_system_score_gemma":0.0006287969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001828089,"about_ca_topic_score_gemma":0.002245072,"domain_scores_codex":[0.9994614,0.00006811484,0.00007010533,0.0001208465,0.0001325125,0.0001471609],"domain_scores_gemma":[0.999116,0.0001125115,0.0002771059,0.00007696485,0.00005007205,0.0003673406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001328311,0.0002474565,0.0003571547,0.00005674054,0.00003171542,0.0004410371,0.00007287956,0.0001494734,0.9960299,0.0004234719,0.0001757555,0.0006860392],"study_design_scores_gemma":[0.0003538534,0.0007090678,0.004530946,0.00002568454,0.0001369414,0.001195871,0.00018462,0.002557821,0.9870977,0.000296361,0.002873504,0.00003764385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906031,0.001084075,0.00360505,0.0005174449,0.0001792957,0.00009418385,0.001558644,0.0004902412,0.001867981],"genre_scores_gemma":[0.9868427,0.001069476,0.002274667,0.0002008154,0.00005069493,0.0001209831,0.001142279,0.0002273189,0.008070986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003145486,"threshold_uncertainty_score":0.01052272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04447585082130959,"score_gpt":0.3261524541936726,"score_spread":0.281676603372363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}