{"id":"W2192402885","doi":"10.1126/sciadv.1500199","title":"Cystic fibrosis–adapted <i>Pseudomonas aeruginosa</i> quorum sensing <i>lasR</i> mutants cause hyperinflammatory responses","year":2015,"lang":"en","type":"article","venue":"Science Advances","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier de l’Université de Montréal; University of British Columbia; McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Cystic Fibrosis Canada; National Institutes of Health; Cystic Fibrosis Foundation; Burroughs Wellcome Fund","keywords":"Quorum sensing; Pseudomonas aeruginosa; Cystic fibrosis; Microbiology; Mutant; Biology; Genetics; Biofilm; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001685672,0.0004678466,0.0002836007,0.0002054495,0.0001602716,0.0002438242,0.0001944308,0.000462373,0.002300385],"category_scores_gemma":[0.0002849871,0.0001601724,0.000305257,0.0001162334,0.0003479925,0.0001975993,0.0002679152,0.0006916908,0.0004244905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001850192,"about_ca_system_score_gemma":0.0001683889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001340096,"about_ca_topic_score_gemma":0.001266248,"domain_scores_codex":[0.9997222,0.00005598623,0.00003343773,0.00004907894,0.000078254,0.00006095335],"domain_scores_gemma":[0.9997358,0.00004300055,0.00009830898,0.00002920739,0.00003051529,0.00006315622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005650069,0.00003789993,0.0004610667,0.00001135766,0.000004689276,0.00008804119,0.00001448628,0.00002476566,0.9986172,0.00004323783,0.00008198496,0.0005588545],"study_design_scores_gemma":[0.00004459017,0.0008494526,0.0554135,0.00002078799,0.00004321077,0.002068304,0.0002238916,0.001128871,0.9371784,0.0002094439,0.002791722,0.00002783174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995788,0.0003154489,0.001937673,0.0002725071,0.00004134334,0.00002235945,0.0004474708,0.00009152645,0.001083692],"genre_scores_gemma":[0.9961478,0.0001765453,0.001466705,0.0001978076,0.00001331702,0.00002870388,0.0004026656,0.0000361413,0.001530278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002300385,"threshold_uncertainty_score":0.007695556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168563932508548,"score_gpt":0.2646620398897353,"score_spread":0.2478056466388805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}