{"id":"W2192402885","doi":"10.1126/sciadv.1500199","title":"Cystic fibrosis–adapted <i>Pseudomonas aeruginosa</i> quorum sensing <i>lasR</i> mutants cause hyperinflammatory responses","year":2015,"lang":"en","type":"article","venue":"Science Advances","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier de l’Université de Montréal; University of British Columbia; McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Cystic Fibrosis Canada; National Institutes of Health; Cystic Fibrosis Foundation; Burroughs Wellcome Fund","keywords":"Quorum sensing; Pseudomonas aeruginosa; Cystic fibrosis; Microbiology; Mutant; Biology; Genetics; Biofilm; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006715069,0.0002520846,0.0002170975,0.0001013251,0.0003570296,0.0001380179,0.0003384278,0.0001041161,0.000003502404],"category_scores_gemma":[0.0006102534,0.0002270462,0.00006313139,0.0004275832,0.0008712073,0.00007636271,0.0002397023,0.0001016396,0.00003581471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004474935,"about_ca_system_score_gemma":0.0005919294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002470827,"about_ca_topic_score_gemma":0.00006364668,"domain_scores_codex":[0.9978421,0.0000877661,0.0002898383,0.0006830217,0.0004347741,0.0006625092],"domain_scores_gemma":[0.9987085,0.00003411943,0.0001467732,0.0005182946,0.000261937,0.0003303907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002758691,0.00001472677,0.0004650664,0.000007438327,0.00000665077,0.00002871272,0.00006538152,0.00007289487,0.9912795,0.0000282021,0.0002075879,0.007548003],"study_design_scores_gemma":[0.0004225759,0.0002345996,0.0006203069,0.00004012663,0.00001310863,0.0001636918,0.0003657044,0.00005287473,0.9122173,0.0000390283,0.08548535,0.0003452999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956774,0.001447756,0.0001479295,0.0002374483,0.001158757,0.0001512076,0.00002548742,0.00005617333,0.001097867],"genre_scores_gemma":[0.9917095,0.0000769672,0.007072124,0.0003883285,0.0003256249,0.000002253532,0.00001556623,0.00002423031,0.0003854636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08527776,"threshold_uncertainty_score":0.9258677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168563932508548,"score_gpt":0.2646620398897353,"score_spread":0.2478056466388805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}