{"id":"W2193465684","doi":"10.1021/acsami.5b10074","title":"Toward Infection-Resistant Surfaces: Achieving High Antimicrobial Peptide Potency by Modulating the Functionality of Polymer Brush and Peptide","year":2015,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Polymer brush; Antimicrobial; Antimicrobial peptides; Peptide; Materials science; Polymer; Combinatorial chemistry; Circular dichroism; Conjugated system; Bacteria; Adhesion; Nanotechnology; Biofilm; Chemistry; Organic chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005828683,0.0003356236,0.0005474744,0.00005975116,0.0002957792,0.0001215165,0.0002373854,0.0002235132,0.0002623409],"category_scores_gemma":[0.00005337232,0.0002478393,0.00003553232,0.00008922251,0.0005787216,0.0002107056,0.0003189849,0.0002105865,0.00005917932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004275405,"about_ca_system_score_gemma":0.00005973433,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007373918,"about_ca_topic_score_gemma":0.0001024792,"domain_scores_codex":[0.9982983,0.0001785779,0.0006222322,0.0004281356,0.00007934529,0.000393421],"domain_scores_gemma":[0.9989849,0.0001574837,0.0004419247,0.0002859184,0.00009971515,0.00003007227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004870562,0.00007754812,0.0003622235,0.00008419393,0.0002021198,5.19674e-7,0.0007995875,0.00005287616,0.9896683,0.001150718,0.006787617,0.0003272422],"study_design_scores_gemma":[0.0007140418,0.0001128465,0.001730084,0.00008280278,0.00008006247,0.00002425688,0.0008704137,1.997315e-7,0.9950568,0.0002507233,0.0007993316,0.0002784126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963999,0.0007403699,0.0000582522,0.0004374256,0.0008404988,0.0003050973,0.0003918004,0.000081797,0.0007448607],"genre_scores_gemma":[0.9981529,0.0001201165,0.00008499869,0.0002044678,0.00008174402,0.0000185374,0.000134823,0.00003476106,0.001167685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007271439,"threshold_uncertainty_score":0.9999974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068552422460854,"score_gpt":0.2256363858180735,"score_spread":0.2049508615934649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}