{"id":"W2193548141","doi":"10.1152/ajpregu.2000.278.4.r1064","title":"Regulation of NHE3 activity by G protein subunits in renal brush-border membranes","year":2000,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"G protein; Brush border; Chemistry; Pertussis toxin; GTP-binding protein regulators; G alpha subunit; Guanosine; Molecular biology; Phosphorylation; Cell biology; Internal medicine; Receptor; Endocrinology; Vesicle; Protein subunit; Biochemistry; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002023774,0.0003255313,0.0008679139,0.0001412687,0.00007369651,0.000006020378,0.0002114821,0.0001450921,0.000168491],"category_scores_gemma":[0.00001376367,0.0002537459,0.0001710957,0.0002843622,0.001226252,0.00003958815,0.00002396651,0.0002753043,0.00000220851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002513111,"about_ca_system_score_gemma":0.0001102071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009193785,"about_ca_topic_score_gemma":0.00006862175,"domain_scores_codex":[0.9980841,0.0005152822,0.0005754596,0.0003875902,0.0001622254,0.0002752908],"domain_scores_gemma":[0.9985906,0.000048788,0.0007062202,0.0002274023,0.0003375824,0.00008942989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002607501,0.0002372319,0.0005613916,0.00001779516,0.000157547,4.50777e-7,0.0005496608,0.0009441837,0.990193,0.0001779656,0.0002272171,0.004326067],"study_design_scores_gemma":[0.0009706054,0.00192627,0.3219982,0.00006492262,0.00002481793,0.00001042447,0.0006299524,0.0002079883,0.6720696,0.0006072783,0.001260734,0.0002291829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988102,0.0004534164,0.0001707541,0.0001034906,0.00005034914,0.000222703,0.00002635627,0.000004760034,0.0001580026],"genre_scores_gemma":[0.9990247,0.0001631497,0.0002060421,0.00006442959,0.000145794,0.0000179697,0.00008599239,0.00001493429,0.0002769979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3214368,"threshold_uncertainty_score":0.9999915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029907392737607,"score_gpt":0.2654159378562295,"score_spread":0.2551168639288534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}