{"id":"W2193610513","doi":"10.1038/ncomms10124","title":"PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Cas9; Guide RNA; Genome editing; Computational biology; Biology; DNA; RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278397,0.0001356056,0.0001071155,0.00005364632,0.000133589,0.00002849349,0.0006517732,0.0002785768,0.000008536916],"category_scores_gemma":[0.0004955922,0.0001458452,0.00005278211,0.0001144717,0.00004384581,0.000003970818,0.0006476464,0.0004220793,0.00004730974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003313293,"about_ca_system_score_gemma":0.00006688283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002415255,"about_ca_topic_score_gemma":0.0002070572,"domain_scores_codex":[0.999243,0.00005820186,0.0001701319,0.0002229044,0.0001070351,0.00019875],"domain_scores_gemma":[0.9983206,0.00003233946,0.00004234708,0.001250927,0.0001734664,0.0001803327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002232891,0.00008799613,0.00667086,0.000009610315,0.00004592135,0.000001107584,0.000383348,0.001419026,0.9064573,0.0002640165,0.08365981,0.0009786722],"study_design_scores_gemma":[0.0004299574,0.0001327783,0.008135374,0.00001746552,0.00002233448,0.00001906896,0.0004699429,0.001061191,0.214303,0.000109909,0.7749381,0.0003608257],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454355,0.02528419,0.008985966,0.004483268,0.0007986642,0.0006049651,0.00008896548,0.0001131216,0.0142053],"genre_scores_gemma":[0.9721814,0.0001313439,0.02570444,0.0008702758,0.0004695813,0.00004136473,0.0003016437,0.00002604822,0.0002739153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6921543,"threshold_uncertainty_score":0.5947395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596522800154552,"score_gpt":0.3372317103344616,"score_spread":0.321266482332916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}