{"id":"W2193610513","doi":"10.1038/ncomms10124","title":"PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Cas9; Guide RNA; Genome editing; Computational biology; Biology; DNA; RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007962526,0.00062524,0.0006539489,0.0003737937,0.0004224761,0.001148287,0.0006058813,0.0006194875,0.002231286],"category_scores_gemma":[0.001364349,0.0004993853,0.0003598932,0.0002621428,0.0008167489,0.0006518911,0.0007337403,0.001155643,0.0008912057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004743225,"about_ca_system_score_gemma":0.0002905811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002822883,"about_ca_topic_score_gemma":0.0004894779,"domain_scores_codex":[0.9986778,0.0003539287,0.000116765,0.0002682134,0.0004467779,0.0001364343],"domain_scores_gemma":[0.99864,0.0005157442,0.0003415897,0.0002627788,0.0001033509,0.0001365334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006174973,0.00001528884,0.0002434317,0.00004527674,0.000005089914,0.00006464728,0.0000128866,0.0002219432,0.9978518,0.0004293588,0.00002061738,0.001027845],"study_design_scores_gemma":[0.000004600044,0.00016354,0.00127705,0.000008346007,0.00001340634,0.0003327185,0.00001175494,0.00114805,0.9957817,0.0002027995,0.001045585,0.00001054468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9487816,0.001452151,0.04140573,0.0001659084,0.00009644396,0.00007531679,0.0002232563,0.0006931441,0.007106384],"genre_scores_gemma":[0.9900849,0.0003016412,0.008175475,0.00007460584,0.00001093388,0.00002424753,0.0001541693,0.00006800269,0.001105997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002231286,"threshold_uncertainty_score":0.007464468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596522800154552,"score_gpt":0.3372317103344616,"score_spread":0.321266482332916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}