{"id":"W2194014097","doi":"10.1056/nejmoa1400382","title":"Breast-Cancer Risk in Families with Mutations in <i>PALB2</i>","year":2014,"lang":"en","type":"letter","venue":"New England Journal of Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":855,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Lunenfeld-Tanenbaum Research Institute; Children's Hospital of Eastern Ontario","funders":"National Cancer Institute; National Institutes of Health; Cancer Research UK","keywords":"Breast cancer; PALB2; Medicine; Oncology; Germline mutation; Cancer; Internal medicine; Population; Family history; Risk factor; Mutation; Genetics; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005239507,0.0002313469,0.0004563729,0.0003522721,0.00002365065,0.000009206446,0.0002520898,0.000322346,0.00007705846],"category_scores_gemma":[0.0001058443,0.0001585654,0.00005517425,0.0002220701,0.000159855,0.000005329846,0.00002097371,0.001180521,0.000001480129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001014191,"about_ca_system_score_gemma":0.0006297131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005757642,"about_ca_topic_score_gemma":0.001805186,"domain_scores_codex":[0.9984436,0.0001909986,0.0005501265,0.0002320529,0.0003543875,0.000228859],"domain_scores_gemma":[0.9988681,0.00009699852,0.0005324599,0.0002358834,0.0001967285,0.00006985142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003595953,0.00002460438,0.02892445,0.00006632753,0.0001727865,0.0002570044,0.0005840446,0.003362677,0.001000652,0.000001518312,0.9036478,0.06159856],"study_design_scores_gemma":[0.02409973,0.0006753433,0.009134443,0.0008178047,0.0001797563,0.001710984,0.0001478278,0.00002267102,0.0002932993,0.0002255397,0.9624326,0.0002600277],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1773037,0.008583184,0.001831246,0.8090466,0.001389168,0.0003163122,0.0000869908,0.000006026426,0.001436775],"genre_scores_gemma":[0.5973451,0.01501998,0.002171036,0.3157466,0.06737345,0.00004482717,0.0003864912,0.0001657425,0.001746781],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4933,"threshold_uncertainty_score":0.646611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008796877053895188,"score_gpt":0.2597942894511698,"score_spread":0.2509974123972746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}