{"id":"W2194135672","doi":"10.3899/jrheum.150710","title":"The Genetic Epidemiological Landscape of Hip and Knee Osteoarthritis: Where Are We Now and Where Are We Going?","year":2015,"lang":"en","type":"review","venue":"The Journal of Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genome-wide association study; Heritability; Epigenetics; Genetic association; Penetrance; Genetic architecture; Disease; Medicine; Genetics; Phenotype; Missing heritability problem; Candidate gene; Genetic epidemiology; Biomarker; Bioinformatics; Computational biology; Biology; Genotype; Gene; Genetic variants; Pathology; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009211751,0.0006939883,0.001758088,0.002385416,0.0002804809,0.0009740647,0.0008949507,0.001129415,0.003333132],"category_scores_gemma":[0.001548485,0.0002601386,0.0007237321,0.002451381,0.0004827105,0.001253951,0.0006445069,0.001392811,0.001398357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006568916,"about_ca_system_score_gemma":0.001592997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002176634,"about_ca_topic_score_gemma":0.003757528,"domain_scores_codex":[0.999738,0.00005805395,0.00004677524,0.00004439073,0.00009322608,0.0000195946],"domain_scores_gemma":[0.9992942,0.0003665281,0.0001092164,0.00001506043,0.0001652918,0.00004961889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006871014,0.00003000656,0.0004587397,0.02421889,0.0002116207,0.0001651707,0.00005782096,0.0001625526,0.0004773138,0.002237774,0.02327631,0.9486352],"study_design_scores_gemma":[0.00003458649,0.00009665153,0.004326708,0.01659576,0.0006229214,0.002578537,0.0001543097,0.0001083218,0.0002357086,0.003699532,0.9715057,0.00004113739],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005621294,0.9991659,0.0000451653,0.0004022639,0.0000793943,0.000001977616,0.00001339048,0.00000323287,0.0002324967],"genre_scores_gemma":[0.0003834009,0.9991837,0.00009017233,0.0001312603,0.00008013153,0.000002316536,0.00001752389,5.967381e-7,0.0001109581],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003333132,"threshold_uncertainty_score":0.01115042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0420047178648394,"score_gpt":0.3065489154976992,"score_spread":0.2645441976328598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}