{"id":"W2194139052","doi":"10.1371/journal.pone.0143846","title":"Safety and Proof-of-Concept Study of Oral QLT091001 in Retinitis Pigmentosa Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT)","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"QLT (Canada); McGill University Health Centre","funders":"National Institute for Health and Care Research; Canadian Institutes of Health Research; National Eye Institute; Johns Hopkins Bloomberg School of Public Health; National Human Genome Research Institute; Johns Hopkins University","keywords":"RPE65; Retinitis pigmentosa; Lecithin; Pigment; Retinal; Ophthalmology; Acyltransferase; Biology; Cell biology; Medicine; Chemistry; Biochemistry; Retinal pigment epithelium; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005027696,0.0002150394,0.0004828656,0.0001195379,0.00003376308,0.00001074337,0.0002121401,0.0001130649,0.00002478906],"category_scores_gemma":[0.0003873187,0.0001880187,0.00003809136,0.000311125,0.0001697122,0.000009764221,0.0001477343,0.0001032173,7.147269e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002362852,"about_ca_system_score_gemma":0.0002289723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002211529,"about_ca_topic_score_gemma":0.0003530291,"domain_scores_codex":[0.9980103,0.0001789247,0.0006803097,0.0003846323,0.0004734552,0.0002723574],"domain_scores_gemma":[0.9991499,0.00001726517,0.0001716737,0.0002641804,0.0002713427,0.0001256367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008207629,0.005815591,0.04177152,0.0003222419,0.000187784,0.00002605993,0.00674638,0.00003750055,0.9337723,0.00002761427,0.00004860677,0.003036794],"study_design_scores_gemma":[0.003763613,0.006585394,0.0126009,0.0002998612,0.00005528552,0.000004005823,0.003756958,0.00002472678,0.9725406,0.00003209494,0.00007258447,0.000263931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972639,0.0001830478,0.0001989256,0.0001612853,0.00002011616,0.001763345,0.00004629177,0.000007177097,0.0003558811],"genre_scores_gemma":[0.9967429,0.00002543915,0.002832394,0.0000303422,0.00001694269,0.00009433926,0.0000433934,0.00002022783,0.0001940148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03876836,"threshold_uncertainty_score":0.766718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04894217223669953,"score_gpt":0.2531391234397906,"score_spread":0.204196951203091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}