{"id":"W2194186986","doi":"10.1074/jbc.m115.698449","title":"Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Demethylase; Histone; Lysine; Chemistry; Biochemistry; Histone H3; Biology; DNA; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005121981,0.0001162896,0.0003310688,0.00002181378,0.00001706253,0.000003210512,0.0002662301,0.0002508441,0.0000106201],"category_scores_gemma":[0.0005240822,0.00007259384,0.0002118934,0.0001262813,0.0002123375,0.000003762321,0.00009529921,0.0001194955,1.661482e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001787487,"about_ca_system_score_gemma":0.0001332577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003751312,"about_ca_topic_score_gemma":3.966838e-7,"domain_scores_codex":[0.9987586,0.00008972931,0.0007032716,0.0001244392,0.0002177334,0.0001062084],"domain_scores_gemma":[0.9980096,0.00002973836,0.001135944,0.0002222774,0.0005257688,0.00007666659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001989613,0.0001468532,0.006980482,0.00004041079,0.00004976065,9.175045e-7,0.00002931795,0.00003417944,0.9918804,0.000004643277,0.00002836121,0.0006057138],"study_design_scores_gemma":[0.0005417395,0.000393077,0.02447773,0.00003884348,0.00003064233,0.000007088926,0.00005290848,0.000007607363,0.9721367,0.0002416298,0.001996937,0.00007511708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996337,0.00191557,0.001169374,0.0000839316,0.00009591602,0.00006156507,0.00003184296,0.000001408229,0.0003033713],"genre_scores_gemma":[0.9982063,0.0005336365,0.0009290665,0.00002308684,0.0001813003,0.00000116615,0.00004119892,0.00000701702,0.00007729819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01974371,"threshold_uncertainty_score":0.2960291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03218631455615131,"score_gpt":0.2881929831729831,"score_spread":0.2560066686168319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}