{"id":"W2194393752","doi":"10.1074/jbc.m115.655076","title":"ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre","funders":"Japan Society for the Promotion of Science; Medical Research Council; Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; Kyowa Hakko Kirin; Alzheimer's Society; Wellcome Trust; Japan Health Sciences Foundation","keywords":"Transporter; Amyloid (mycology); Chemistry; Function (biology); Biochemistry; ATP-binding cassette transporter; Cell biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503738,0.0004224968,0.0005159673,0.0004231064,0.0001717647,0.0004873553,0.0002313476,0.0008531644,0.002406201],"category_scores_gemma":[0.0002673637,0.0002007502,0.0004378058,0.0002680759,0.0003915504,0.0003151799,0.0002255303,0.0006606593,0.0004377279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752458,"about_ca_system_score_gemma":0.00021282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006204279,"about_ca_topic_score_gemma":0.0006519069,"domain_scores_codex":[0.9997491,0.00004589589,0.00003275902,0.00005208289,0.00006046921,0.0000596987],"domain_scores_gemma":[0.9998066,0.00004190211,0.00006027957,0.00001720558,0.00002606003,0.0000478948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002711391,0.00007490623,0.000802109,0.00004676233,0.00002659766,0.0005340686,0.00002133893,0.00004696049,0.9961079,0.0001570082,0.0001099919,0.001801215],"study_design_scores_gemma":[0.0001297636,0.001935033,0.05147804,0.00002819163,0.0002818863,0.00620854,0.000202138,0.002194291,0.9283063,0.0006587298,0.008541496,0.00003567197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963273,0.001221992,0.001167399,0.0001669906,0.00006049891,0.00001587363,0.0003043288,0.00007493281,0.0006607108],"genre_scores_gemma":[0.9960626,0.0009844913,0.000617964,0.0001273227,0.00001462341,0.00003626692,0.0003297818,0.00003648742,0.001790501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002406201,"threshold_uncertainty_score":0.008049548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08413872488006423,"score_gpt":0.331851748380877,"score_spread":0.2477130235008128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}