{"id":"W2194557575","doi":"10.1126/scitranslmed.aad0295","title":"RANKL blockade prevents and treats aggressive osteosarcomas","year":2015,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Ontario Institute for Cancer Research","keywords":"Denosumab; RANKL; Blockade; Osteosarcoma; Cancer research; Medicine; Antibody; Oncology; Internal medicine; Immunology; Receptor; Osteoporosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583172,0.0005839721,0.0005459987,0.0003639023,0.0001457942,0.0002294133,0.0002207326,0.0002890264,0.0007314518],"category_scores_gemma":[0.00007666992,0.0001313718,0.0003538354,0.0001593027,0.0002111845,0.0001444746,0.0002193515,0.0008769217,0.0003098084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516041,"about_ca_system_score_gemma":0.0004555912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005691648,"about_ca_topic_score_gemma":0.001286775,"domain_scores_codex":[0.9998716,0.00001988864,0.00001088244,0.00001447385,0.00004351376,0.00003964679],"domain_scores_gemma":[0.9999403,0.00000717594,0.00001531077,0.000007529879,0.000007643426,0.00002216314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002247314,0.001651038,0.0009501243,0.000566135,0.00009202788,0.0006249987,0.00009347934,0.0007613872,0.9095583,0.001178633,0.002682063,0.0795945],"study_design_scores_gemma":[0.002240191,0.02367597,0.01712518,0.00008925294,0.000417118,0.004250929,0.0001037854,0.002964349,0.8323028,0.0009941235,0.1157782,0.00005821719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586986,0.02993618,0.003359079,0.0007143332,0.0002605585,0.0001701976,0.0006481835,0.0006972708,0.005515561],"genre_scores_gemma":[0.9768792,0.01527992,0.001662479,0.0002766843,0.000134847,0.0001035407,0.001067741,0.00003495688,0.004560609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007314518,"threshold_uncertainty_score":0.00244689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02506537796873123,"score_gpt":0.3036025401886728,"score_spread":0.2785371622199415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}