{"id":"W2194675780","doi":"10.1158/2326-6066.cir-15-0141","title":"Subacute CNS Demyelination after Treatment with Nivolumab for Melanoma","year":2015,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Nivolumab; Ipilimumab; Medicine; Melanoma; Immunotherapy; Pathology; Immunology; Oncology; Immune system; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003480197,0.0006250279,0.0004977161,0.0004737662,0.0008258798,0.0004013333,0.0004084925,0.001151219,0.0006527788],"category_scores_gemma":[0.00125948,0.0001996891,0.0003646319,0.0002925224,0.00059424,0.0004256401,0.0003530024,0.001393017,0.0002648798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001001906,"about_ca_system_score_gemma":0.0005129969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002122056,"about_ca_topic_score_gemma":0.004279643,"domain_scores_codex":[0.9997259,0.00008705354,0.00003432935,0.00004344862,0.00004836967,0.00006089233],"domain_scores_gemma":[0.9993119,0.0002075917,0.0001836239,0.00006327211,0.00006314781,0.0001704622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00145707,0.0003658982,0.04569204,0.0002486307,0.000212483,0.8939932,0.0007323705,0.0005973314,0.02058697,0.0003799188,0.0006975461,0.03503666],"study_design_scores_gemma":[0.0002447744,0.004012296,0.0777958,0.0001382675,0.0002092632,0.8927884,0.0004259971,0.002443966,0.01605412,0.001033381,0.004812154,0.00004164366],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871151,0.004604401,0.002024555,0.0008510473,0.0001112847,0.0001033004,0.00003894475,0.00008881514,0.005062426],"genre_scores_gemma":[0.9979908,0.0006289337,0.0002365653,0.0005011816,0.0001003213,0.00001161967,0.00003653345,0.000007852057,0.0004860885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002122056,"threshold_uncertainty_score":0.007269382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1130613754195761,"score_gpt":0.4120534297064699,"score_spread":0.2989920542868938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}