{"id":"W2194929222","doi":"10.1136/jclinpath-2015-203395","title":"Selective estrogen receptor modulators and betulinic acid act synergistically to target ERα and SP1 transcription factor dependent Pygopus expression in breast cancer","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Pathology","topic":"Phytochemistry and Bioactive Compounds","field":"Materials Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. John’s Health Sciences Centre; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Betulinic acid; Estrogen receptor; Transcription factor; Estrogen; Fulvestrant; Cancer research; Breast cancer; Estrogen receptor alpha; Oestrogen receptor; Estrogen receptor beta; Cancer; Biology; Medicine; Bioinformatics; Internal medicine; Endocrinology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409668,0.0002451702,0.0002830906,0.0002142071,0.0001313457,0.0001635603,0.0001525727,0.0001542526,0.001265938],"category_scores_gemma":[0.0001407946,0.0001445587,0.0001586775,0.0001505031,0.0001455308,0.00009685921,0.000198274,0.0002494279,0.0002351883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001646779,"about_ca_system_score_gemma":0.0001411221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002109009,"about_ca_topic_score_gemma":0.0008113435,"domain_scores_codex":[0.999911,0.00001514242,0.000005663222,0.00001625761,0.00002561726,0.00002624988],"domain_scores_gemma":[0.9999418,0.00001240491,0.00001583245,0.0000057945,0.00000644711,0.0000177267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001547707,0.00002035561,0.0007021012,0.00003036717,0.000009120581,0.00003512623,0.000008356619,0.00004812196,0.9968889,0.00001813369,0.00002432092,0.002060293],"study_design_scores_gemma":[0.00006575072,0.001099427,0.02659942,0.000008173703,0.00004328596,0.0007056448,0.00006054682,0.0005528062,0.967674,0.00005612641,0.003131507,0.00000336093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952605,0.003030606,0.0007688712,0.00006143943,0.0000149045,0.00001939195,0.0001110907,0.00003252699,0.0007005828],"genre_scores_gemma":[0.9955239,0.0017159,0.0008282904,0.00005384381,0.00001073643,0.00002767192,0.000288557,0.000008400769,0.001542795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265938,"threshold_uncertainty_score":0.004235029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05266298423964366,"score_gpt":0.3627327067495405,"score_spread":0.3100697225098968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}