{"id":"W2195080078","doi":"10.1016/s0303-7207(01)00545-7","title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin increases steady-state estrogen receptor-β mRNA levels after CYP1A1 and CYP1B1 induction in rat granulosa cells in vitro11Part of the work communicated in this paper was presented in the 82nd (Toronto, Canada) Annual Meetings of the Endocrine Society. All cDNA clones used in the present experiments are available from the laboratory of Professor Hutz.","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"U.S. Public Health Service","keywords":"Aromatase; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor; Internal medicine; CYP1B1; Endocrinology; Estrogen; Estrogen receptor; Messenger RNA; Estrogen receptor alpha; Cytochrome P450; Chemistry; Biology; Gene expression; Metabolism; Transcription factor; Gene; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005284623,0.0002895134,0.0004097752,0.00004523254,0.0000701075,0.00001361388,0.0006807047,0.0002037134,0.00001788263],"category_scores_gemma":[0.0000741404,0.0001610429,0.0001057588,0.0003992503,0.0004390399,0.00002416728,0.0003840908,0.0006046451,2.36172e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005547881,"about_ca_system_score_gemma":0.0001477021,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.08576122,"about_ca_topic_score_gemma":0.08179909,"domain_scores_codex":[0.9959265,0.002265472,0.0006154797,0.0003933346,0.0003325106,0.0004666905],"domain_scores_gemma":[0.9986457,0.000180765,0.0002872761,0.0007836735,0.00006808078,0.00003456214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000439523,0.0003922243,0.1482148,0.00003326388,0.00009749234,0.00006353009,0.003336401,0.00007017077,0.8468349,0.00001232887,0.000425962,0.0000794173],"study_design_scores_gemma":[0.002111445,0.0001020139,0.04838676,0.0001337214,0.00004202885,0.00001538432,0.006055331,0.00002338949,0.9408162,0.00001978568,0.00211478,0.0001791078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748645,0.02295699,7.119813e-7,0.0009006187,0.00007918399,0.001053254,0.00008891645,0.000002743517,0.00005306401],"genre_scores_gemma":[0.9979681,0.001449047,0.00001933465,0.0002805305,0.00001744113,0.000160478,0.00004462193,0.00002151195,0.00003895482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09982806,"threshold_uncertainty_score":0.9349557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00943168117052254,"score_gpt":0.2212752556769288,"score_spread":0.2118435745064062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}