{"id":"W2195328025","doi":"","title":"Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial.","year":2004,"lang":"en","type":"article","venue":"PubMed","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Leflunomide; Rheumatoid arthritis; Internal medicine; Methotrexate; Rheumatology; Placebo; Combination therapy; Gastroenterology; Randomized controlled trial; Nausea; Randomization; Arthritis; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003516954,0.00238226,0.004799251,0.0007478726,0.0005829483,0.001074603,0.00127978,0.002641529,0.007686225],"category_scores_gemma":[0.002368624,0.0009882136,0.002030294,0.0006084301,0.00149599,0.001531458,0.0005395907,0.002944281,0.001443935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005993053,"about_ca_system_score_gemma":0.001141718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000536362,"about_ca_topic_score_gemma":0.001083532,"domain_scores_codex":[0.9985583,0.0008077348,0.0001192704,0.0002433652,0.00011377,0.0001574504],"domain_scores_gemma":[0.9981375,0.0005092136,0.0004502861,0.0001819093,0.000137561,0.0005835427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.98229,0.006584934,0.0002635194,0.0004500326,0.0002755943,0.00003438514,0.00002230978,0.00009113635,0.002072912,0.00002765443,0.0002020863,0.007685451],"study_design_scores_gemma":[0.9554518,0.04353217,0.0004475509,0.00001388958,0.00009953295,0.00001767217,0.00000383337,0.00007905373,0.0001623919,0.00001700409,0.0001703272,0.000004806294],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976153,0.009114881,0.001156703,0.0007175982,0.0009357872,0.008414979,0.001402627,0.0002444182,0.00185989],"genre_scores_gemma":[0.9731031,0.004920606,0.003421311,0.001034938,0.001509092,0.01113845,0.001423551,0.00003294727,0.003416098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007686225,"threshold_uncertainty_score":0.02571297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0386115079581038,"score_gpt":0.2992968190942929,"score_spread":0.2606853111361891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}