{"id":"W2195333861","doi":"10.1016/j.ymeth.2015.12.004","title":"Vascular smooth muscle cell differentiation from human stem/progenitor cells","year":2015,"lang":"en","type":"review","venue":"Methods","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Heart and Stroke Foundation; University of Toronto; Toronto General Hospital; University Health Network; Ted Rogers Centre for Heart Research; Canada Research Chairs","funders":"Canadian Institutes of Health Research; Core Research for Evolutional Science and Technology; Heart and Stroke Foundation of Canada","keywords":"Induced pluripotent stem cell; Embryonic stem cell; Cell biology; Progenitor cell; Regenerative medicine; Stem cell; Vascular smooth muscle; Biology; Transplantation; Directed differentiation; Endothelial stem cell; Adult stem cell; Angiogenesis; Neural crest; Cancer research; Immunology; Anatomy; Medicine; Internal medicine; Endocrinology; Genetics; Smooth muscle; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001202501,0.0004840671,0.001102456,0.0001290744,0.0001086896,0.00009016621,0.0005632663,0.0007227807,0.0001308656],"category_scores_gemma":[0.00004744888,0.0004232097,0.0007859263,0.0002030964,0.00005830914,0.00000380532,0.000527273,0.0004024004,0.0001645407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008792884,"about_ca_system_score_gemma":0.0002873114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007036479,"about_ca_topic_score_gemma":0.00001667941,"domain_scores_codex":[0.9955544,0.002242103,0.0005217752,0.0008629739,0.0003776208,0.0004410513],"domain_scores_gemma":[0.9980674,0.00009848985,0.000205783,0.001197343,0.0001721128,0.0002588709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002847112,0.00007133011,0.000001729726,0.00189908,0.00014521,0.000004215544,0.00001412226,1.722305e-7,0.04873711,9.09477e-7,0.0007520253,0.9483712],"study_design_scores_gemma":[0.0002368919,0.000132463,0.00001047268,0.0002524102,0.0004778852,8.424441e-7,0.000008291788,0.000006102,0.01512581,0.00002848095,0.9832845,0.0004358338],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001680948,0.9920091,0.003933899,0.000001231049,0.000507415,0.0009485118,0.0001669485,0.00002803802,0.0007239002],"genre_scores_gemma":[0.00005984848,0.9797124,0.01479895,0.00001042139,0.000976961,0.0002063632,0.001376113,0.0001603071,0.002698587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9825325,"threshold_uncertainty_score":0.999822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09991577243707156,"score_gpt":0.4389027590341629,"score_spread":0.3389869865970914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}