{"id":"W2195955429","doi":"10.1074/jbc.m115.704098","title":"Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Transcription factor; Cytotoxicity; Signal transduction; Chemistry; Calcium signaling; Cell biology; Calcineurin; Transcription (linguistics); Cancer research; Tacrolimus; Calcium; Biology; Internal medicine; Medicine; Biochemistry; In vitro; Gene; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285743,0.0002302293,0.0002485455,0.0002921233,0.0002125251,0.0003278789,0.0001981436,0.0001898834,0.001004454],"category_scores_gemma":[0.0001705536,0.0001109707,0.0002443483,0.0001975833,0.0003095306,0.0001590938,0.0001377493,0.000465831,0.0003144382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003367091,"about_ca_system_score_gemma":0.000304733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007004751,"about_ca_topic_score_gemma":0.001034154,"domain_scores_codex":[0.9998693,0.00001933951,0.00001423563,0.00002412655,0.00003744049,0.00003560611],"domain_scores_gemma":[0.9998796,0.00002392583,0.00003137319,0.00002202388,0.00001438588,0.0000286455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000131646,0.00002127641,0.00009846999,0.00001031564,0.000002338576,0.00002660434,0.000006219247,0.00002367661,0.9989896,0.00003448312,0.00001491997,0.0006404325],"study_design_scores_gemma":[0.00001648823,0.00018936,0.003525796,0.000002400313,0.00001204015,0.00014748,0.00002173987,0.0006203495,0.9941499,0.00003523113,0.001276405,0.000002769259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951211,0.001364331,0.001973657,0.0000966236,0.00003970359,0.00001818588,0.0002251256,0.00008386058,0.00107736],"genre_scores_gemma":[0.994027,0.0007962114,0.001760366,0.00003680591,0.00001613832,0.00004131496,0.0005724273,0.00002416591,0.002725689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004454,"threshold_uncertainty_score":0.003360271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06616758790240379,"score_gpt":0.2733151180704773,"score_spread":0.2071475301680735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}