{"id":"W2196030797","doi":"10.1124/dmd.115.066829","title":"Metabolism of Oral Turinabol by Human Steroid Hormone–Synthesizing Cytochrome P450 Enzymes","year":2015,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"World Anti-Doping Agency","keywords":"Steroid; Cholesterol side-chain cleavage enzyme; Chemistry; Cytochrome P450; Stereochemistry; Steroid 11-beta-hydroxylase; Enzyme; Hydroxylation; Biochemistry; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001807968,0.0002550407,0.0002876527,0.000198743,0.0001224846,0.0002859595,0.00009715292,0.0001521894,0.001598574],"category_scores_gemma":[0.000429163,0.0001319805,0.0002035319,0.0002328863,0.0001695027,0.0001486725,0.00008830351,0.0002939866,0.0002435866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003638269,"about_ca_system_score_gemma":0.000294037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002984279,"about_ca_topic_score_gemma":0.00235875,"domain_scores_codex":[0.9998668,0.00007961185,0.000005606195,0.00001684195,0.00001519417,0.00001592144],"domain_scores_gemma":[0.9998912,0.00002849977,0.0000465715,0.00001247257,0.000009670645,0.00001155305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02926666,0.0005229379,0.1202846,0.0007734685,0.0008100827,0.002439406,0.0005099992,0.00366948,0.4566576,0.001179282,0.00227835,0.3816082],"study_design_scores_gemma":[0.00173153,0.02014623,0.471416,0.0001323216,0.0008277841,0.006865861,0.0004344492,0.00773247,0.4712348,0.000551533,0.01886057,0.00006637273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895595,0.005458155,0.001680969,0.0001274998,0.00001293967,0.0000607251,0.0003801952,0.00006991509,0.002649999],"genre_scores_gemma":[0.996686,0.001539165,0.0005875046,0.00003317519,0.00001221324,0.00001270707,0.0002003057,0.000006920594,0.0009218655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002984279,"threshold_uncertainty_score":0.005933821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0719171909990786,"score_gpt":0.3874007805826685,"score_spread":0.3154835895835899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}