{"id":"W2196030797","doi":"10.1124/dmd.115.066829","title":"Metabolism of Oral Turinabol by Human Steroid Hormone–Synthesizing Cytochrome P450 Enzymes","year":2015,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"World Anti-Doping Agency","keywords":"Steroid; Cholesterol side-chain cleavage enzyme; Chemistry; Cytochrome P450; Stereochemistry; Steroid 11-beta-hydroxylase; Enzyme; Hydroxylation; Biochemistry; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001419007,0.0005360947,0.0009363521,0.0002943203,0.0003558863,0.00007568335,0.0004125494,0.000323567,0.0002062735],"category_scores_gemma":[0.00006147308,0.0005031024,0.000198615,0.0003416622,0.0003984626,0.00049954,0.0002261973,0.0005797129,0.00005714925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003056401,"about_ca_system_score_gemma":0.00008187802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001901698,"about_ca_topic_score_gemma":0.000007821826,"domain_scores_codex":[0.9965622,0.0008287401,0.0007915542,0.0006243212,0.000483563,0.0007095616],"domain_scores_gemma":[0.9980798,0.0001298227,0.0003909121,0.0003620249,0.0002623351,0.0007751271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005143554,0.0007621023,0.0002442069,0.00006618331,0.0002810143,0.00001911656,0.002565685,0.00005665699,0.9525498,0.0112649,0.01367996,0.01799603],"study_design_scores_gemma":[0.007608118,0.00007478428,0.01777784,0.00001933361,0.001378134,0.00004139922,0.0006309873,0.0004477245,0.6059287,0.003437958,0.3618517,0.0008033347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9224423,0.07232909,0.0002273298,0.0004145379,0.0007815932,0.0005651804,0.0005771476,0.0001177961,0.002545071],"genre_scores_gemma":[0.9946802,0.002337606,0.0004766475,0.0009818908,0.0004983282,0.00009814835,0.0002279534,0.00006662946,0.0006325882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3481717,"threshold_uncertainty_score":0.999742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0719171909990786,"score_gpt":0.3874007805826685,"score_spread":0.3154835895835899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}