{"id":"W2196085380","doi":"10.1002/anie.201510494","title":"Use of Trifluoromethyl Groups for Catalytic Benzylation and Alkylation with Subsequent Hydrodefluorination","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Alkylation; Chemistry; Aryl; Alkyl; Electrophile; Trifluoromethyl; Catalysis; Medicinal chemistry; Friedel–Crafts reaction; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004187342,0.0001576367,0.0001649265,0.0001124351,0.00005545723,0.00002834614,0.0001099465,0.0002002313,0.0000915413],"category_scores_gemma":[0.0004868671,0.0001563255,0.00004409884,0.0001354686,0.0001194204,0.0005544431,0.00003770418,0.000190258,0.000004691998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512474,"about_ca_system_score_gemma":0.00007707048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003489832,"about_ca_topic_score_gemma":0.00001108924,"domain_scores_codex":[0.9989257,0.00003088709,0.000325647,0.0002720653,0.0002904746,0.0001552592],"domain_scores_gemma":[0.9985563,0.0003618055,0.0002617985,0.0001210718,0.0005751752,0.0001238691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00190296,0.0004638252,0.01126087,0.0002006595,0.0004088,0.000009134351,0.00112392,0.001245532,0.9543907,0.003398016,0.01481366,0.01078194],"study_design_scores_gemma":[0.002048176,0.0001504505,0.001296278,0.00002825764,0.0001076275,0.00003535541,0.00007762754,0.003312238,0.9719238,0.001464124,0.01939096,0.0001651378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843296,0.0001642463,0.01004837,0.001686929,0.001436226,0.0005189088,0.0003086912,0.00008335912,0.001423675],"genre_scores_gemma":[0.9953465,0.00005657164,0.001371728,0.0001307448,0.0008095441,0.00008562875,0.00164808,0.00002347385,0.00052773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01753308,"threshold_uncertainty_score":0.6374769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1491452870615916,"score_gpt":0.3872052777414221,"score_spread":0.2380599906798305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}