{"id":"W2196190612","doi":"10.1016/s1473-3099(15)00348-5","title":"Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study","year":2015,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":304,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Tenofovir alafenamide; Medicine; Emtricitabine; Cobicistat; Regimen; Tolerability; Internal medicine; Rilpivirine; Clinical endpoint; Elvitegravir; Pharmacology; Viral load; Adverse effect; Gastroenterology; Clinical trial; Human immunodeficiency virus (HIV); Virology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001630906,0.001437154,0.002725143,0.0003982309,0.000381821,0.001086785,0.0007989891,0.001734314,0.004494305],"category_scores_gemma":[0.002092113,0.0005972118,0.001903047,0.0004000726,0.001218962,0.001310976,0.0003310766,0.002757887,0.0005722768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006668122,"about_ca_system_score_gemma":0.0007729502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001219768,"about_ca_topic_score_gemma":0.00223065,"domain_scores_codex":[0.9991361,0.0004227948,0.00006246622,0.0001412433,0.00007048374,0.0001669747],"domain_scores_gemma":[0.9988532,0.0004591684,0.0002012857,0.00009885633,0.00005479154,0.0003327602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9706711,0.008917865,0.0006276693,0.000412877,0.0008143225,0.0000376592,0.0001007747,0.0002570912,0.002760128,0.00006614169,0.0002586802,0.01507565],"study_design_scores_gemma":[0.8995351,0.09649746,0.002547064,0.00002672433,0.0003776079,0.00002687832,0.00004044473,0.0002676882,0.0003209911,0.0001112066,0.0002323942,0.00001658674],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961798,0.001491674,0.000292583,0.0001761887,0.000205676,0.0007670593,0.0002632267,0.00003386855,0.0005900157],"genre_scores_gemma":[0.9956696,0.001045921,0.0006938193,0.0004556896,0.0002222848,0.0007571836,0.0002850102,0.00001268447,0.0008578534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004494305,"threshold_uncertainty_score":0.01503497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03418472364530394,"score_gpt":0.3281702941383671,"score_spread":0.2939855704930631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}