{"id":"W2196190612","doi":"10.1016/s1473-3099(15)00348-5","title":"Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study","year":2015,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":304,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Tenofovir alafenamide; Medicine; Emtricitabine; Cobicistat; Regimen; Tolerability; Internal medicine; Rilpivirine; Clinical endpoint; Elvitegravir; Pharmacology; Viral load; Adverse effect; Gastroenterology; Clinical trial; Human immunodeficiency virus (HIV); Virology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006367273,0.0006378489,0.001862417,0.0002172533,0.0003862504,0.0002450227,0.0003725598,0.0001114646,0.00004196561],"category_scores_gemma":[0.0008327367,0.0003728653,0.0001540009,0.0005011079,0.00009267284,0.000441912,0.0002614826,0.0003615547,0.00007313955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004068443,"about_ca_system_score_gemma":0.0004620568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287961,"about_ca_topic_score_gemma":0.002350112,"domain_scores_codex":[0.9966986,0.0004248232,0.0006818358,0.000893032,0.0004917333,0.0008099689],"domain_scores_gemma":[0.997323,0.0007158697,0.0003380553,0.0007922732,0.0002834269,0.0005473778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3426532,0.01344004,0.633047,0.00006292104,0.001233563,0.0002718035,0.003827605,0.0001702244,0.0005277676,0.000008667177,0.001197031,0.003560177],"study_design_scores_gemma":[0.7542943,0.007473506,0.2300211,0.0003710836,0.00182577,0.00002259546,0.001131637,0.003069815,0.0002307845,0.0002051355,0.0006643902,0.0006898589],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802371,0.0001266384,0.0007753416,0.001712804,0.0002041594,0.01562481,0.0003142978,0.0002892093,0.0007156743],"genre_scores_gemma":[0.9928192,0.00005794954,0.000546638,0.0007479205,0.000445878,0.004481241,0.0002939941,0.00006976868,0.0005373409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4116412,"threshold_uncertainty_score":0.9998723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03418472364530394,"score_gpt":0.3281702941383671,"score_spread":0.2939855704930631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}