{"id":"W2196369193","doi":"10.1016/j.cjca.2015.11.022","title":"Sirtuins, Cell Senescence, and Vascular Aging","year":2015,"lang":"en","type":"review","venue":"Canadian Journal of Cardiology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":254,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"SIRT3; SIRT6; SIRT2; Senescence; Telomere; Medicine; Sirtuin; Vascular smooth muscle; Nicotinamide adenine dinucleotide; Cell biology; NAD+ kinase; Biology; Endocrinology; Cancer research; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009945798,0.0009107427,0.00176667,0.002228807,0.0004045164,0.001159557,0.0009178516,0.001573555,0.003880773],"category_scores_gemma":[0.001181975,0.0003240742,0.0006295266,0.002711219,0.0006909638,0.001065323,0.0008261439,0.002064259,0.001317002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006504677,"about_ca_system_score_gemma":0.001692493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002869813,"about_ca_topic_score_gemma":0.008073313,"domain_scores_codex":[0.9997821,0.00003452841,0.00003889323,0.00003617284,0.00008734519,0.00002093551],"domain_scores_gemma":[0.9994981,0.0002198913,0.00008033719,0.00001366672,0.0001356295,0.000052385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002120171,0.0001189224,0.000540689,0.02320372,0.0002984019,0.0002352505,0.00008999545,0.0002793456,0.00153019,0.003544566,0.0394619,0.930485],"study_design_scores_gemma":[0.0000633102,0.0001391682,0.002587467,0.004475746,0.000532917,0.0009200944,0.0001358226,0.00011844,0.0004394118,0.002578582,0.9879721,0.00003709186],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007446441,0.999057,0.00004716875,0.0002567289,0.000181024,0.000002097077,0.00001351597,0.000003560839,0.0003643211],"genre_scores_gemma":[0.0005554781,0.99865,0.00007871851,0.0001499806,0.0002585599,0.000003069561,0.0000199558,4.700098e-7,0.000283737],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003880773,"threshold_uncertainty_score":0.01298249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03738845858267629,"score_gpt":0.3033212776016996,"score_spread":0.2659328190190233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}