{"id":"W2196845493","doi":"10.3390/life6010002","title":"Perspectives and Insights into the Competition for Aminoacyl-tRNAs between the Translational Machinery and for tRNA Dependent Non-Ribosomal Peptide Bond Formation","year":2015,"lang":"en","type":"review","venue":"Life","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Transfer RNA; Transferase; Biochemistry; Amino acid; Biology; Enzyme; Nucleotide; Aminoacyl tRNA synthetase; Escherichia coli; Peptidyl transferase; Ribosomal RNA; Competition (biology); Peptide bond; Protein biosynthesis; Amino Acyl-tRNA Synthetases; RNA; Ribosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003918082,0.0002348516,0.0003925995,0.0000371751,0.0002734277,0.00006965027,0.0001652653,0.0002195055,0.000001295913],"category_scores_gemma":[0.00007696123,0.0001324389,0.0001704643,0.0000314303,0.00007908014,0.00001213394,0.0000465412,0.00009337156,9.295682e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001328312,"about_ca_system_score_gemma":0.0001058254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007298313,"about_ca_topic_score_gemma":0.00002602074,"domain_scores_codex":[0.9990421,0.0001055542,0.000294557,0.0002860832,0.0001343205,0.000137383],"domain_scores_gemma":[0.9992812,0.0001713207,0.0002015574,0.000190836,0.0000860472,0.00006905333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002103209,0.00006393825,0.00002849496,0.006404792,0.0007632056,6.14422e-7,0.005643296,0.000004744137,0.002313047,0.0121071,0.001395802,0.9710646],"study_design_scores_gemma":[0.0005648275,0.0002668244,0.00005149124,0.0003876542,0.0004951639,0.00001509838,0.0006015852,0.00005010302,0.0008612461,0.00528218,0.9911342,0.0002896826],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003186044,0.9699238,0.02404707,0.0003942806,0.00007772355,0.002051911,0.000164037,0.000006148517,0.0001489731],"genre_scores_gemma":[0.0250853,0.9687397,0.00275215,0.0001017937,0.0009936276,0.0009117546,0.00119199,0.00004856357,0.0001750587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9897383,"threshold_uncertainty_score":0.54007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03717184940690226,"score_gpt":0.3070922796776533,"score_spread":0.269920430270751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}