{"id":"W2198042669","doi":"10.1371/journal.pone.0126311","title":"Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"CXCR3; FOXP3; NOD mice; Nod; Chemokine; Islet; Biology; Pancreatic islets; Homing (biology); Chemokine receptor; Immunology; Insulitis; T cell; Cell biology; Autoimmunity; Cancer research; Immune system; Endocrinology; Insulin; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690254,0.0005792119,0.0003485765,0.0006547702,0.0002409887,0.0003791727,0.0001861118,0.0003786125,0.002245396],"category_scores_gemma":[0.0001083485,0.0003181342,0.0003347554,0.0001688577,0.00030723,0.0003107746,0.0001819352,0.001369808,0.0006516236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002677533,"about_ca_system_score_gemma":0.0001849755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006469739,"about_ca_topic_score_gemma":0.0009362244,"domain_scores_codex":[0.9997196,0.00002193748,0.00002800526,0.00008670103,0.00004498729,0.00009889556],"domain_scores_gemma":[0.9996789,0.00001509574,0.0001032293,0.000021672,0.0000178862,0.0001632794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003821515,0.00008393005,0.0006591509,0.00003247814,0.000003065133,0.00008460147,0.00003490103,0.00004167533,0.9976851,0.0000801699,0.00005326921,0.0008594928],"study_design_scores_gemma":[0.0002363561,0.002160435,0.05410899,0.00006477906,0.00007336545,0.001730152,0.0002271171,0.001615155,0.9357295,0.0002301555,0.003796863,0.00002711016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994119,0.0009472555,0.001535483,0.0001044408,0.0000426958,0.00003897294,0.000959212,0.000184685,0.002068242],"genre_scores_gemma":[0.988905,0.0008057838,0.002319471,0.0001881909,0.00004310735,0.0001257608,0.001244462,0.000118404,0.006249704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002245396,"threshold_uncertainty_score":0.007511616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464952934761684,"score_gpt":0.1976893082268731,"score_spread":0.1830397788792563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}