{"id":"W2198189555","doi":"10.1182/blood.v120.21.1586.1586","title":"A 7-Gene Microrna Signature Characteristic of Mantle Cell Lymphoma Reveals Focal Adhesion and Integrin Signalling, Proteasome-Mediated Degradation, and the PI3K Signalling Cascade As Important to MCL Pathogenesis","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Alberta; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Queen's University; University of Toronto; Toronto General Hospital; University Health Network; BC Cancer Agency; Kingston General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Mantle cell lymphoma; Cancer research; Biology; Cyclin D1; microRNA; Pathogenesis; Lymphoma; Cell cycle; Immunology; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096844,0.0001179565,0.0001952207,0.0004580735,0.0001344936,0.0002293383,0.00007872309,0.0001458915,0.000915114],"category_scores_gemma":[0.0002138135,0.0001093335,0.0001499117,0.000265353,0.0001771215,0.00006949108,0.0001443467,0.0001641074,0.0001831876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001317881,"about_ca_system_score_gemma":0.0001097459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002998755,"about_ca_topic_score_gemma":0.0007158042,"domain_scores_codex":[0.9998958,0.00001496104,0.000009055794,0.00002724365,0.00003080822,0.00002215305],"domain_scores_gemma":[0.9998398,0.00003689461,0.00006778233,0.0000124783,0.00001860924,0.0000243665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004866303,0.00003060383,0.05730022,0.00005857548,0.00001889618,0.0003530738,0.00009339906,0.0001113677,0.9366177,0.0000835658,0.00009049242,0.004755538],"study_design_scores_gemma":[0.00004240818,0.0005848948,0.8341718,0.00001683874,0.0000971258,0.00362692,0.0003885994,0.002118198,0.1561242,0.0002390328,0.002576686,0.0000132172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983549,0.0003548153,0.0006162131,0.00001617277,0.000002813762,0.00001169655,0.0002722371,0.0000196485,0.0003514205],"genre_scores_gemma":[0.9976484,0.0001081767,0.001435571,0.0000313748,0.000004912854,0.00002135315,0.0004797406,0.000005657573,0.000264731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000915114,"threshold_uncertainty_score":0.003061354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009596013486732861,"score_gpt":0.2270264599741165,"score_spread":0.2174304464873836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}