{"id":"W2198207772","doi":"10.1038/cdd.2015.152","title":"The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial–mesenchymal transition in a sumoylation-regulated manner","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Cancer Foundation","keywords":"SUMO protein; Ubiquitin ligase; Epithelial–mesenchymal transition; Ubiquitin; Cell biology; Transforming growth factor; Gene knockdown; Deubiquitinating enzyme; Chemistry; Biology; Transforming growth factor beta; Cell migration; Cancer research; Downregulation and upregulation; Cell; Cell culture; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338851,0.0001344553,0.00009464697,0.00004513983,0.0001116282,0.0000717682,0.00008303852,0.0001173117,0.000007548759],"category_scores_gemma":[0.00006823501,0.0001066914,0.00004021411,0.0000589761,0.00002810913,0.00001108935,0.00002945524,0.0000589461,0.000005231592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001405872,"about_ca_system_score_gemma":0.00006276523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003794105,"about_ca_topic_score_gemma":0.00007249957,"domain_scores_codex":[0.9991251,0.0001005365,0.0002054319,0.0002441244,0.0001327102,0.000192134],"domain_scores_gemma":[0.9995272,0.00002677666,0.00007085387,0.0001786686,0.00008422804,0.000112332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003529962,0.000212133,0.01149456,0.00004092275,0.00002264548,0.000003855963,0.0005475963,0.0003613164,0.9847926,0.00009034754,0.0003291434,0.001751869],"study_design_scores_gemma":[0.001481699,0.0001600905,0.07600111,0.00002400164,0.00003808736,0.000002775259,0.0001877508,0.002478698,0.9183056,0.0004755484,0.0006396797,0.0002049751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980454,0.0008158741,0.0005280384,0.00009721644,0.0001263211,0.000198542,0.00001627472,0.00001794445,0.0001543892],"genre_scores_gemma":[0.9989901,0.00005836321,0.00004276766,0.00004592058,0.0001359142,0.00002924844,0.0005098505,0.00001529718,0.0001725921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06648703,"threshold_uncertainty_score":0.4350749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577940472693251,"score_gpt":0.2350466071994707,"score_spread":0.2192672024725382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}