{"id":"W2198287101","doi":"10.1002/anie.201510057","title":"Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Serine; Enzyme; Antibiotics; Nucleophile; Chemistry; Metabolite; Stereochemistry; Biochemistry; Combinatorial chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527906,0.0003692185,0.0002306848,0.0002489347,0.0002224626,0.0002878151,0.0002176772,0.0002543751,0.001747218],"category_scores_gemma":[0.0001729216,0.0001042109,0.0002144086,0.0002604406,0.0001361139,0.0003036605,0.0002535233,0.0003874516,0.0006320423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494983,"about_ca_system_score_gemma":0.000581368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003978041,"about_ca_topic_score_gemma":0.0006524113,"domain_scores_codex":[0.9998801,0.00001933736,0.00001456176,0.00002148361,0.00003269055,0.00003187583],"domain_scores_gemma":[0.9999225,0.00001113349,0.00001343018,0.0000124309,0.00001792003,0.00002258548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001314316,0.00008232593,0.0001174617,0.0001700912,0.0000136704,0.0001330445,0.00003306151,0.0004281174,0.985556,0.0008492551,0.0001462531,0.01233926],"study_design_scores_gemma":[0.00001462513,0.0004367501,0.0003125599,0.0000105797,0.00001092016,0.0001235979,0.000008048967,0.000271535,0.9923963,0.0001165825,0.006292696,0.000005794811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9415045,0.0126244,0.01578243,0.0002436491,0.0001299395,0.0001894281,0.001904578,0.0002796769,0.02734151],"genre_scores_gemma":[0.9870328,0.002990092,0.004571023,0.00004561001,0.00001461206,0.00004278274,0.0007490306,0.00002869915,0.004525475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747218,"threshold_uncertainty_score":0.00584501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02015066766534204,"score_gpt":0.2518226856978576,"score_spread":0.2316720180325156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}