{"id":"W2198360076","doi":"10.1021/acschembio.5b00398","title":"Type II Inhibitors Targeting CDK2","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Diamond Light Source; Wellcome Trust; Structural Genomics Consortium; Novartis","keywords":"Cyclin-dependent kinase 2; Biology; Chemistry; Computational biology; Cell biology; Kinase; Protein kinase A","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037063,0.0004626437,0.0003013889,0.0001282583,0.0001302173,0.0003772769,0.0002537399,0.0002068039,0.001530446],"category_scores_gemma":[0.0001265952,0.0001241317,0.0001655282,0.0001508816,0.0001403533,0.0002035865,0.0001682401,0.0004016321,0.0004517615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005067579,"about_ca_system_score_gemma":0.0002460979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008460705,"about_ca_topic_score_gemma":0.001425591,"domain_scores_codex":[0.9999075,0.00001308212,0.000005792218,0.00002399336,0.00003036063,0.00001924032],"domain_scores_gemma":[0.9999554,0.000007583842,0.00001373317,0.000005258668,0.000007433584,0.00001064824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002554456,0.00005622253,0.0007172078,0.00020456,0.00002440797,0.0001213375,0.00001623402,0.001203693,0.9809602,0.001931966,0.001021072,0.01348752],"study_design_scores_gemma":[0.00005992935,0.0003146926,0.001501567,0.00001143,0.00002733731,0.000547224,0.0000116084,0.003355866,0.9623138,0.0002907128,0.03155417,0.00001169355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.888733,0.04188662,0.03405627,0.0005565686,0.0004011179,0.0002802245,0.002105755,0.0007249643,0.03125545],"genre_scores_gemma":[0.9664667,0.01216156,0.009771015,0.0002455108,0.00005923112,0.0001119168,0.001015822,0.00007734998,0.01009089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530446,"threshold_uncertainty_score":0.005119801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330990393807192,"score_gpt":0.2794488683506669,"score_spread":0.256138964412595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}