{"id":"W2198811857","doi":"10.1212/nxi.0000000000000104","title":"B lymphocytes in neuromyelitis optica","year":2015,"lang":"en","type":"review","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"National Eye Institute; Chugai Pharmaceutical; Novartis Pharma; Genentech; Multiple Sclerosis Society; Myelin Repair Foundation; National Institutes of Health; Guthy-Jackson Charitable Foundation; Questcor Pharmaceuticals; Biogen; U.S. Department of Defense; Sanofi; Pfizer; Eli Lilly and Company; Myasthenia Gravis Foundation of America; Deutsche Forschungsgemeinschaft; National Multiple Sclerosis Society; National Institute of Neurological Disorders and Stroke; Teva Pharmaceutical Industries; U.S. Department of Veterans Affairs; Alnylam Pharmaceuticals","keywords":"Neuromyelitis optica; Autoantibody; Immunology; Aquaporin 4; Astrocyte; Pathogenesis; B cell; Proinflammatory cytokine; Autoimmunity; Medicine; Autoimmune disease; Inflammation; Biology; Neuroscience; Antibody; Pathology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0006278138,0.00129053,0.004724367,0.002157855,0.0001728681,0.00006010887,0.0008161672,0.001290966,0.0001107421],"category_scores_gemma":[0.00330863,0.001152649,0.0007658023,0.001417912,0.0008487891,0.0002570452,0.000881955,0.003506347,0.001047184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996561,"about_ca_system_score_gemma":0.001346902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004231128,"about_ca_topic_score_gemma":0.00002724243,"domain_scores_codex":[0.9912257,0.002424046,0.002167891,0.00193386,0.0007460532,0.001502444],"domain_scores_gemma":[0.9951851,0.001503619,0.0007982848,0.001839283,0.0003524554,0.0003213079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005266595,0.000240615,0.0001621077,0.004607321,0.0001801578,0.003900368,0.00007225181,0.00001217608,0.0002220874,0.0001233928,0.0008606191,0.9890922],"study_design_scores_gemma":[0.0025761,0.001697725,0.01253285,0.001315335,0.0005152628,0.004973656,0.000004597804,0.0001590231,0.000008343121,0.0000505906,0.9756142,0.0005522833],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007849172,0.9813498,0.000001892019,0.002144204,0.001307441,0.003778655,0.00005537558,0.0004699688,0.003043541],"genre_scores_gemma":[0.0002961091,0.9972333,0.00005321578,0.0004880474,0.0003808778,0.0006260238,0.000360046,0.0002848942,0.0002774621],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9885399,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1084296824621547,"score_gpt":0.381109265506451,"score_spread":0.2726795830442963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}