{"id":"W2199017299","doi":"10.1021/acs.joc.5b02014","title":"Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-<i>cis</i>-Disubstituted Tetrahydropyran of Neopeltolide","year":2015,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Foundation for Innovation; University of Ottawa","keywords":"Chemistry; Conjugate; Diastereomer; Pyran; Tetrahydropyran; Ring (chemistry); Stereochemistry; Ketone; Bicyclic molecule; Natural product; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008246656,0.0002534498,0.0001391698,0.0001025819,0.00009834967,0.0002415172,0.0001915591,0.0001596322,0.001547414],"category_scores_gemma":[0.0001228699,0.0001214713,0.0001460006,0.0000965444,0.0001445478,0.0003151514,0.0002919944,0.00031607,0.0005250848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001901718,"about_ca_system_score_gemma":0.0001918558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002482159,"about_ca_topic_score_gemma":0.0004803389,"domain_scores_codex":[0.9999548,0.00000495597,0.000003170381,0.00001272525,0.000008514485,0.00001580994],"domain_scores_gemma":[0.9999592,0.000005509723,0.00001096691,0.000005955874,0.00000635947,0.00001197177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002755255,0.00009611344,0.0008267292,0.0002211761,0.00001948752,0.0006487896,0.0001428183,0.004021649,0.9700207,0.007298341,0.0004136976,0.01601487],"study_design_scores_gemma":[0.00002403059,0.0005154043,0.0005101152,0.000008612691,0.00001340752,0.0002683544,0.00002638861,0.004328093,0.9885681,0.0004845884,0.005238996,0.00001382634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976273,0.0003370768,0.01038109,0.00006479285,0.00005078045,0.00004637957,0.0002408605,0.0001179671,0.01248811],"genre_scores_gemma":[0.9932873,0.0003252806,0.004079417,0.0000231188,0.000003321089,0.00001845865,0.0001324661,0.00002122275,0.002109441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547414,"threshold_uncertainty_score":0.005176663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02342000473430585,"score_gpt":0.2450293072441998,"score_spread":0.221609302509894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}