{"id":"W2199695484","doi":"10.1038/nrmicro3569","title":"An updated evolutionary classification of CRISPR–Cas systems","year":2015,"lang":"en","type":"review","venue":"Nature Reviews Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2570,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Université Laval","funders":"Biotechnology and Biological Sciences Research Council; National Institutes of Health; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"CRISPR; Biology; Horizontal gene transfer; Computational biology; Genetics; Archaea; Locus (genetics); Phylogenetic tree; Evolutionary biology; Acquired immune system; Phylogenetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001219787,0.001140968,0.001582579,0.003078178,0.0003403654,0.001719812,0.001521913,0.001303428,0.002538038],"category_scores_gemma":[0.001449851,0.0004030141,0.0005784354,0.002661957,0.001272514,0.002126717,0.0009861271,0.002850143,0.001385735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001160059,"about_ca_system_score_gemma":0.001562326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001093935,"about_ca_topic_score_gemma":0.001816508,"domain_scores_codex":[0.9993925,0.00007261496,0.000106358,0.0001318873,0.0002337151,0.00006289127],"domain_scores_gemma":[0.9992307,0.0003365794,0.00008894326,0.00003390237,0.0002519647,0.00005782126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007548757,0.00002867372,0.0002576779,0.00835171,0.00007505871,0.0001941735,0.00007894057,0.0004313348,0.008117207,0.01637472,0.02951405,0.9365008],"study_design_scores_gemma":[0.00001092347,0.00005522433,0.0004473056,0.001197819,0.00007930862,0.001122356,0.00003879812,0.0001737392,0.002111914,0.004225006,0.9905,0.00003763194],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005063057,0.988417,0.004576604,0.00149095,0.001259533,0.0000206653,0.0001058174,0.00009749153,0.003525687],"genre_scores_gemma":[0.003180037,0.985767,0.00596744,0.001762688,0.0005777091,0.00002675875,0.0002339465,0.00002225677,0.002462212],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003078178,"threshold_uncertainty_score":0.008490562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02811041282076009,"score_gpt":0.3912146332336279,"score_spread":0.3631042204128678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}