{"id":"W2200204073","doi":"10.1007/s10689-015-9824-x","title":"Risk of colorectal cancer for people with a mutation in both a MUTYH and a DNA mismatch repair gene","year":2015,"lang":"en","type":"article","venue":"Familial Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"MUTYH; Germline mutation; MLH1; MSH2; Lynch syndrome; PMS2; DNA mismatch repair; Mutation; Medicine; Cancer research; Gene mutation; Colorectal cancer; Genetics; Cancer; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003527192,0.0004686943,0.0004738828,0.001215704,0.0007885702,0.0005120074,0.000385218,0.001179001,0.009426666],"category_scores_gemma":[0.002171319,0.0003568498,0.001365674,0.001010076,0.0003017799,0.0004333767,0.0004403556,0.001188862,0.0006272431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177542,"about_ca_system_score_gemma":0.0002913592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00965898,"about_ca_topic_score_gemma":0.007997375,"domain_scores_codex":[0.9997208,0.0000824405,0.00002003881,0.00005881438,0.00004338654,0.00007457395],"domain_scores_gemma":[0.9989771,0.000232316,0.0003275938,0.00008467993,0.00007415091,0.0003041628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005966728,0.0001012164,0.9927729,0.0000340627,0.000273579,0.001117205,0.0001375585,0.00007701799,0.0009260258,0.0001276872,0.0005971253,0.003239009],"study_design_scores_gemma":[0.0000378472,0.0004488844,0.9920873,0.00002695367,0.0004341786,0.004785763,0.0003861937,0.0005565187,0.0001782662,0.0002583002,0.0007803221,0.00001948889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926168,0.001237191,0.0003665374,0.0006326,0.00008841609,0.0000113184,0.0007003509,0.00004739944,0.004299369],"genre_scores_gemma":[0.9969765,0.0003100194,0.000259376,0.0001139639,0.00008329016,0.000008372359,0.0002898262,0.00000646909,0.001952213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00965898,"threshold_uncertainty_score":0.03153527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0183426001628982,"score_gpt":0.2864862693560903,"score_spread":0.2681436691931921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}