{"id":"W2200423187","doi":"10.1080/19420862.2015.1119352","title":"CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors","year":2015,"lang":"en","type":"article","venue":"mAbs","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Medical Research Council; National Health and Medical Research Council; CSL Limited; State Government of Victoria; Australian Synchrotron; Australian Cancer Research Foundation","keywords":"Immunology; Cytokine; Eosinophil; Monoclonal antibody; Receptor; Epitope; Biology; Pharmacology; Antibody; Medicine; Asthma; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252281,0.0001551656,0.0002730593,0.00002588897,0.0001204036,0.000009899282,0.0001435329,0.00004977341,0.00001497651],"category_scores_gemma":[0.00007293328,0.00005934771,0.000158433,0.0001242684,0.0003668531,0.00002508326,0.00003190701,0.00004873658,0.000001314382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003481689,"about_ca_system_score_gemma":0.0001186132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001045465,"about_ca_topic_score_gemma":0.00001526745,"domain_scores_codex":[0.9991089,0.00008065246,0.0002297078,0.0001511897,0.000267186,0.0001623419],"domain_scores_gemma":[0.9989271,0.000343506,0.0001500796,0.0003607294,0.0001020741,0.0001164909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007661084,0.009360231,0.5516706,0.0005226664,0.002476592,0.0000123805,0.008032661,0.0001007094,0.06820831,0.0009975769,0.0357648,0.3151924],"study_design_scores_gemma":[0.01353141,0.005056493,0.3898913,0.0002339043,0.0022375,0.00002665707,0.006523613,0.003600268,0.01534467,0.0003727339,0.5628036,0.0003778948],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799737,0.01306444,0.00009706647,0.004483642,0.0002054735,0.001190232,0.0008866666,0.00001928455,0.00007944123],"genre_scores_gemma":[0.9984041,0.0003749,0.00001049167,0.0005297817,0.0001007715,0.0000697663,0.00007193425,0.0000194515,0.0004187666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5270388,"threshold_uncertainty_score":0.2420129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02870484268741018,"score_gpt":0.2979676925103594,"score_spread":0.2692628498229492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}