{"id":"W2200423187","doi":"10.1080/19420862.2015.1119352","title":"CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors","year":2015,"lang":"en","type":"article","venue":"mAbs","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Medical Research Council; National Health and Medical Research Council; CSL Limited; State Government of Victoria; Australian Synchrotron; Australian Cancer Research Foundation","keywords":"Immunology; Cytokine; Eosinophil; Monoclonal antibody; Receptor; Epitope; Biology; Pharmacology; Antibody; Medicine; Asthma; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693633,0.0005373094,0.0001899373,0.000374799,0.000136572,0.0002598847,0.0004045453,0.0004474813,0.0008178837],"category_scores_gemma":[0.0001230283,0.0001445658,0.0002523756,0.0002418795,0.000268832,0.0002182117,0.0001959787,0.0006654505,0.0004203928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007030861,"about_ca_system_score_gemma":0.0005325536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009001491,"about_ca_topic_score_gemma":0.001294396,"domain_scores_codex":[0.9998815,0.00001706955,0.000007116894,0.00002112164,0.00004598447,0.00002713759],"domain_scores_gemma":[0.9999468,0.00000828349,0.00001442383,0.000004102886,0.000008285292,0.00001796153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001612089,0.00008970683,0.0003123903,0.0000827265,0.00001099954,0.0001018756,0.00002295517,0.0007004805,0.9823483,0.0005118243,0.0006455394,0.01501197],"study_design_scores_gemma":[0.0002558177,0.001984324,0.003316716,0.00001977866,0.00006055371,0.001410821,0.00001507827,0.003675621,0.9613543,0.00016159,0.02772491,0.0000206281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947033,0.01598234,0.02554372,0.0008771039,0.0001413147,0.0004377668,0.0009172254,0.0004657457,0.008601786],"genre_scores_gemma":[0.9796682,0.00457389,0.009951572,0.0003750269,0.00004522219,0.0001543763,0.00116654,0.00002187511,0.004043396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009001491,"threshold_uncertainty_score":0.005101264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02870484268741018,"score_gpt":0.2979676925103594,"score_spread":0.2692628498229492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}