{"id":"W2200475468","doi":"10.1074/jbc.m115.665125","title":"Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Cystic Fibrosis Trust; Canadian Institutes of Health Research; Western Canada Research Grid; Compute Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette transporter; Gating; Transmembrane protein; Transmembrane domain; Transporter; Chemistry; Biophysics; Cell biology; Homology modeling; Biochemistry; Cystic fibrosis; Chloride channel; Biology; Amino acid; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002702127,0.0002948497,0.0004123814,0.0002519995,0.0004665451,0.0006243373,0.0004019979,0.0009734482,0.006398392],"category_scores_gemma":[0.0004634152,0.00007622501,0.0003471548,0.0005415061,0.0002829714,0.0003253186,0.0003442688,0.0004765743,0.003851909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00067081,"about_ca_system_score_gemma":0.0004895668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002257844,"about_ca_topic_score_gemma":0.001499231,"domain_scores_codex":[0.9997849,0.0000368312,0.00001314056,0.00004585317,0.00008802595,0.00003119843],"domain_scores_gemma":[0.9998736,0.00002159779,0.00003049759,0.00001209742,0.00003904464,0.00002307625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007246094,0.000149556,0.009639453,0.001830816,0.0000903454,0.003522084,0.0002324815,0.002401811,0.6885628,0.02335549,0.05812692,0.2113635],"study_design_scores_gemma":[0.0001452302,0.0005898205,0.01684339,0.000268632,0.0001205299,0.01047569,0.0002075595,0.008498078,0.1922804,0.004156677,0.7663381,0.0000759031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5925978,0.1355851,0.06632001,0.01140718,0.00349951,0.0007191354,0.02387999,0.005767302,0.160224],"genre_scores_gemma":[0.9069473,0.01939293,0.02184303,0.00228545,0.0001932239,0.0001377299,0.01120732,0.0001206271,0.03787237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006398392,"threshold_uncertainty_score":0.02140468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05130314611128518,"score_gpt":0.3205529609604271,"score_spread":0.2692498148491419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}