{"id":"W2200650350","doi":"10.1097/aln.0000000000000943","title":"Inflammation Increases Neuronal Sensitivity to General Anesthetics","year":2015,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Etomidate; Isoflurane; GABAA receptor; Anesthetic; Medicine; Inflammation; Pharmacology; Lipopolysaccharide; Anesthesia; Hippocampal formation; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561067,0.0003724894,0.0004221942,0.0002328655,0.0001270531,0.0003596118,0.0001363481,0.0002721798,0.002389111],"category_scores_gemma":[0.0001852362,0.0001399533,0.0003661312,0.0001668603,0.0001927406,0.0002743542,0.0002170201,0.000786665,0.0003492449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002700097,"about_ca_system_score_gemma":0.0001946601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007806401,"about_ca_topic_score_gemma":0.0009282668,"domain_scores_codex":[0.9997794,0.00002718124,0.00002194159,0.00003857846,0.00005484872,0.00007806654],"domain_scores_gemma":[0.9998434,0.00001930691,0.00004471055,0.00001463751,0.00003680091,0.00004113853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003330148,0.00003469092,0.0003544879,0.00005899396,0.000009909594,0.0000484437,0.0000115131,0.00002067394,0.9978412,0.00002389551,0.00004640998,0.001216717],"study_design_scores_gemma":[0.00004867106,0.002162326,0.05283074,0.00004505263,0.00005551147,0.0004528367,0.0001468418,0.0006273392,0.9424154,0.00008616163,0.001121038,0.00000812692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931258,0.003647734,0.0009341709,0.0001532265,0.00007914543,0.00001954495,0.0002601777,0.00003794836,0.001742171],"genre_scores_gemma":[0.9953561,0.002146972,0.0006525217,0.0001353769,0.00002870778,0.00003289129,0.0002570681,0.000005726944,0.001384446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002389111,"threshold_uncertainty_score":0.007992327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07921777042757856,"score_gpt":0.3138293740987737,"score_spread":0.2346116036711952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}