{"id":"W2200809230","doi":"10.3892/ol.2015.4069","title":"Real-world efficacy, toxicity and clinical management of ipilimumab treatment in metastatic melanoma","year":2015,"lang":"en","type":"article","venue":"Oncology Letters","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Medical Research Council; Canadian Institutes of Health Research; National Health and Medical Research Council; Hunter Cancer Research Alliance","keywords":"Ipilimumab; Medicine; Metastatic melanoma; Melanoma; Toxicity; Molecular medicine; Oncology; Oncogene; Cancer; Internal medicine; Cell cycle; Cancer research; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009213815,0.000128083,0.0005832373,0.0002030396,0.00001398465,0.0000040859,0.00007845897,0.00005648151,0.0001845415],"category_scores_gemma":[0.00002968188,0.0001029857,0.00008896859,0.000207769,0.0002710038,0.00002395739,0.00006914575,0.0001785944,0.00002088764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00067812,"about_ca_system_score_gemma":0.0001333789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004957865,"about_ca_topic_score_gemma":0.0007969908,"domain_scores_codex":[0.9984399,0.0003433369,0.0004373006,0.0002921245,0.0002191611,0.0002681409],"domain_scores_gemma":[0.9989933,0.0003947413,0.00008451107,0.0003033061,0.00002744466,0.0001967153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01105272,0.008780586,0.4564309,0.0002377598,0.002533444,0.006724226,0.001789036,0.00003181988,0.02531392,0.0005516127,0.008771404,0.4777826],"study_design_scores_gemma":[0.0627716,0.01225072,0.8564512,0.0001464883,0.0008049447,0.0001268722,0.0008208972,0.0003256418,0.003744789,0.0001035485,0.06214827,0.000305044],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764609,0.00006301463,0.00001380738,0.008764358,0.0001180647,0.0007598915,0.000002635765,0.00001730903,0.01380003],"genre_scores_gemma":[0.9921121,0.0005186548,0.003184229,0.001198621,0.0000789305,0.00005119776,0.00001345069,0.00002112595,0.002821707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4774775,"threshold_uncertainty_score":0.4199635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1093178192983865,"score_gpt":0.4357684455983323,"score_spread":0.3264506262999458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}