{"id":"W2200831712","doi":"10.1371/journal.pone.0140124","title":"Effects of Adenovirus Type 5 E1A Isoforms on Viral Replication in Arrested Human Cells","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Research Manitoba; Manitoba Health Research Council","keywords":"Biology; Viral replication; Gene isoform; Viral life cycle; Virology; Virus; DNA replication; Viral entry; Gene; Viral protein; Adenovirus infection; Adenoviridae; Molecular biology; Cell biology; Genetics; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000231777,0.0003558992,0.0002156182,0.0002480498,0.0001524543,0.0003324841,0.0001894259,0.0001500582,0.0007567944],"category_scores_gemma":[0.000170965,0.0001360326,0.0002891496,0.0001383378,0.0001501509,0.00016013,0.0001693476,0.0003005777,0.0004291698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003171736,"about_ca_system_score_gemma":0.0002135815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002126522,"about_ca_topic_score_gemma":0.00153088,"domain_scores_codex":[0.9998405,0.00004917818,0.00002638008,0.00002692415,0.0000351141,0.00002189676],"domain_scores_gemma":[0.9998442,0.00007093804,0.00002108555,0.00002458434,0.00002289241,0.00001626066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000292059,0.00004376157,0.0002701898,0.00006832576,0.000008184165,0.00007208624,0.00006147063,0.0001298888,0.996605,0.0001607277,0.00007124247,0.002217078],"study_design_scores_gemma":[0.00001274386,0.0006724067,0.001904704,0.00001081248,0.00001656829,0.000176478,0.0000386772,0.0009939881,0.9913316,0.00004870036,0.004786076,0.000007367922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845023,0.008395682,0.003867828,0.00006637434,0.00007622167,0.0000499687,0.0007133168,0.0001177915,0.002210658],"genre_scores_gemma":[0.9820393,0.005578259,0.006134146,0.00004803283,0.00002372898,0.00005507721,0.001467347,0.00005377421,0.004600328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002126522,"threshold_uncertainty_score":0.004228294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04923602831616191,"score_gpt":0.3042897903814203,"score_spread":0.2550537620652584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}