{"id":"W2200831712","doi":"10.1371/journal.pone.0140124","title":"Effects of Adenovirus Type 5 E1A Isoforms on Viral Replication in Arrested Human Cells","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Research Manitoba; Manitoba Health Research Council","keywords":"Biology; Viral replication; Gene isoform; Viral life cycle; Virology; Virus; DNA replication; Viral entry; Gene; Viral protein; Adenovirus infection; Adenoviridae; Molecular biology; Cell biology; Genetics; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002410831,0.00009030166,0.0001355025,0.00007116122,0.00001893494,0.000006453275,0.0001779415,0.0001044091,0.000008028963],"category_scores_gemma":[0.0001293153,0.00008531301,0.00002502372,0.0001251526,0.00004329198,0.000002695052,0.0000497578,0.00009934951,0.00004930343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003026671,"about_ca_system_score_gemma":0.00006218933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002841923,"about_ca_topic_score_gemma":0.00005818304,"domain_scores_codex":[0.999099,0.00007533807,0.0001539808,0.0002613526,0.0002350727,0.0001752429],"domain_scores_gemma":[0.9992435,0.00001305836,0.00005924476,0.0005083096,0.0001046708,0.00007120566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001356008,0.0008796902,0.0006949203,0.00005472685,0.00005498431,0.000002578505,0.00004145571,0.00001467876,0.9961869,0.00001218783,0.0001991437,0.000502802],"study_design_scores_gemma":[0.0009459659,0.005053005,0.001231269,0.00004258243,0.00001183397,2.04701e-7,0.000006043095,0.00003088261,0.9924072,0.00009243029,0.00008614561,0.00009241606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987455,0.000350813,0.000003834567,0.0000432251,0.0000206466,0.0003520188,0.00000385362,0.000009319298,0.0004707692],"genre_scores_gemma":[0.9990388,0.00005917043,0.0001044798,0.0001049073,0.00008508094,0.00003090694,0.00005974722,0.00002081415,0.0004960913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004173315,"threshold_uncertainty_score":0.3478964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04923602831616191,"score_gpt":0.3042897903814203,"score_spread":0.2550537620652584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}