{"id":"W2200845583","doi":"10.1038/ni.3255","title":"LRRK2 and Nod2 promote lysozyme sorting in Paneth cells","year":2015,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa; University of Toronto","funders":"","keywords":"Paneth cell; NOD2; Lysozyme; Secretion; Crypt; Sorting; Biology; Cell biology; Immunology; Immune system; Genetics; Innate immune system; Biochemistry; Computer science; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003610942,0.0003988346,0.0005381221,0.0001830102,0.00006199317,0.00003824008,0.0004283419,0.003782668,0.00001554897],"category_scores_gemma":[0.0004463924,0.0003610347,0.00007954719,0.0001171303,0.0003071626,0.000004237985,0.0007634576,0.003691597,0.00002048547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006217322,"about_ca_system_score_gemma":0.0002086326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000520832,"about_ca_topic_score_gemma":0.00007357597,"domain_scores_codex":[0.9976707,0.0002751384,0.0003428658,0.0007589093,0.0002100238,0.0007424068],"domain_scores_gemma":[0.9989779,0.00003269646,0.0001943308,0.0005677445,0.0001864226,0.00004092199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008091962,0.00001769767,0.0001292765,0.0000871659,0.0002310816,0.0002302552,0.00006705817,3.545045e-7,0.4901651,0.000002414227,0.5074481,0.00154063],"study_design_scores_gemma":[0.0007079813,0.0003238183,0.0006945793,0.00005130971,0.00002135653,0.00007858982,0.00002428803,0.000002349472,0.0428884,0.000108439,0.9547223,0.0003765889],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5272674,0.09984641,0.00001029707,0.3659463,0.002377667,0.001462645,0.0002380915,0.00007348244,0.002777684],"genre_scores_gemma":[0.3625641,0.02050594,0.00316983,0.5530801,0.01763779,0.0005833261,0.008393288,0.0007420968,0.03332363],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4472767,"threshold_uncertainty_score":0.9998842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009358278072410665,"score_gpt":0.2695241510222816,"score_spread":0.2601658729498709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}