{"id":"W2200845583","doi":"10.1038/ni.3255","title":"LRRK2 and Nod2 promote lysozyme sorting in Paneth cells","year":2015,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa; University of Toronto","funders":"","keywords":"Paneth cell; NOD2; Lysozyme; Secretion; Crypt; Sorting; Biology; Cell biology; Immunology; Immune system; Genetics; Innate immune system; Biochemistry; Computer science; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001102218,0.0004358605,0.0004109941,0.0001897987,0.0007616719,0.001333283,0.0004188895,0.00529347,0.0053836],"category_scores_gemma":[0.002892877,0.0002761542,0.0004763422,0.0001152129,0.0009192852,0.000867692,0.0009462423,0.005715682,0.002144613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001113964,"about_ca_system_score_gemma":0.0004068307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005196062,"about_ca_topic_score_gemma":0.0007248935,"domain_scores_codex":[0.9995092,0.0001064067,0.00004363701,0.00006539836,0.0001626352,0.0001127394],"domain_scores_gemma":[0.9991307,0.0004378325,0.00006387097,0.0001031626,0.0001165045,0.0001480391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004115028,0.0004121498,0.00413208,0.0004044525,0.0001265298,0.01076231,0.0003183703,0.0008610926,0.1671957,0.02334207,0.7023344,0.08599581],"study_design_scores_gemma":[0.001165717,0.001041957,0.007711517,0.0001269817,0.00009823636,0.006705354,0.000543072,0.004489103,0.1635885,0.0222288,0.7921847,0.0001159418],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.05800605,0.01048268,0.004267558,0.8528352,0.04633027,0.0001153454,0.0004247405,0.0005483001,0.02698982],"genre_scores_gemma":[0.5607687,0.009667835,0.005615933,0.2829395,0.03795769,0.0003513971,0.0004565906,0.0001418335,0.1021006],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0053836,"threshold_uncertainty_score":0.01800996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009358278072410665,"score_gpt":0.2695241510222816,"score_spread":0.2601658729498709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}