{"id":"W2201163923","doi":"10.1371/journal.pone.0145772","title":"HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Centers for Disease Control and Prevention; National Institutes of Health; Wellcome Trust; U.S. President’s Emergency Plan for AIDS Relief; World Health Organization; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Resistance mutation; Drug resistance; HIV drug resistance; Genotype; Virology; Viral load; Medicine; Reverse-transcriptase inhibitor; Regimen; Lentivirus; Biology; Reverse transcriptase; Human immunodeficiency virus (HIV); Antiretroviral therapy; Internal medicine; Polymerase chain reaction; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002311919,0.0005660982,0.0005685326,0.0012873,0.0001927559,0.001095502,0.0007821248,0.00130534,0.003267317],"category_scores_gemma":[0.00378062,0.000261949,0.0003591757,0.001103459,0.0003686434,0.0007909223,0.000471541,0.0005403282,0.000785974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004080046,"about_ca_system_score_gemma":0.0003815506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007150668,"about_ca_topic_score_gemma":0.00151372,"domain_scores_codex":[0.9990425,0.0004950282,0.00003893843,0.0001544588,0.0002147842,0.00005436975],"domain_scores_gemma":[0.9980801,0.001060006,0.0002508168,0.0001299135,0.0003749304,0.0001042746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0006654857,0.0003605027,0.09997282,0.0009399116,0.0000653274,0.001484129,0.0002766301,0.00566131,0.0883562,0.004706317,0.005049358,0.792462],"study_design_scores_gemma":[0.0004260107,0.00630333,0.2233376,0.00278316,0.001025545,0.02509534,0.00238368,0.2587383,0.1963895,0.04750744,0.2355454,0.0004646789],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5389469,0.1259333,0.2554695,0.02106948,0.001036792,0.00115149,0.003164548,0.002220001,0.05100797],"genre_scores_gemma":[0.8492268,0.01876188,0.1260183,0.002125592,0.0002899839,0.000157562,0.0006647383,0.00005361775,0.002701532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003267317,"threshold_uncertainty_score":0.0122267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04936263259228917,"score_gpt":0.2603012519101174,"score_spread":0.2109386193178282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}