{"id":"W2201163923","doi":"10.1371/journal.pone.0145772","title":"HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Centers for Disease Control and Prevention; National Institutes of Health; Wellcome Trust; U.S. President’s Emergency Plan for AIDS Relief; World Health Organization; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Resistance mutation; Drug resistance; HIV drug resistance; Genotype; Virology; Viral load; Medicine; Reverse-transcriptase inhibitor; Regimen; Lentivirus; Biology; Reverse transcriptase; Human immunodeficiency virus (HIV); Antiretroviral therapy; Internal medicine; Polymerase chain reaction; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126135,0.0001301461,0.0002840915,0.00009611111,0.0001196584,0.00001280508,0.00008791062,0.0000423931,0.00001384772],"category_scores_gemma":[0.0002514532,0.0001257535,0.00005377454,0.0002835409,0.00005548985,0.00006849293,0.00002176165,0.00007126906,0.00007481682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532545,"about_ca_system_score_gemma":0.0002554231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001661864,"about_ca_topic_score_gemma":0.00004199582,"domain_scores_codex":[0.9988642,0.0000198946,0.0003185364,0.0002624333,0.000335918,0.0001989558],"domain_scores_gemma":[0.9985594,0.0001272084,0.0001386958,0.0002978037,0.0007430288,0.0001338908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01672288,0.04559908,0.2336789,0.04637188,0.01422834,0.0004465993,0.1083303,0.0001854358,0.1505838,0.04774675,0.3163223,0.01978361],"study_design_scores_gemma":[0.07466381,0.001043913,0.03539827,0.01933568,0.01911663,0.00003999286,0.03456365,0.002646716,0.519109,0.06520444,0.2239238,0.004954102],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7158506,0.03299771,0.05202777,0.06408585,0.0002392229,0.02362447,0.001077079,0.001425819,0.1086715],"genre_scores_gemma":[0.4236852,0.00002168866,0.4650308,0.00007231232,0.0001847854,0.001213004,0.000541992,0.00004374619,0.1092065],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.413003,"threshold_uncertainty_score":0.5128077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04936263259228917,"score_gpt":0.2603012519101174,"score_spread":0.2109386193178282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}