{"id":"W2201192914","doi":"10.2174/1389200216888150915112039","title":"Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines","year":2015,"lang":"en","type":"review","venue":"Current Drug Metabolism","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"","keywords":"Cardiotoxicity; Anthracycline; Dexrazoxane; Pharmacology; Drug; Therapeutic index; Hydroxylation; Cytotoxicity; Chemistry; Chemotherapy; Toxicity; Medicine; Enzyme; Cancer; Biochemistry; Breast cancer; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003807663,0.0006081162,0.004966324,0.0004050872,0.00004573366,0.00002159293,0.0004797868,0.0003684097,0.00001383801],"category_scores_gemma":[0.0008058628,0.0003903601,0.001390059,0.000768389,0.0004856935,0.0001276092,0.0001378,0.001343812,0.000007459524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003604051,"about_ca_system_score_gemma":0.0005974639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005601526,"about_ca_topic_score_gemma":0.000011942,"domain_scores_codex":[0.9946635,0.001270546,0.002228504,0.0006487759,0.0008267039,0.0003619202],"domain_scores_gemma":[0.9963992,0.0008706565,0.00124578,0.0009705179,0.0002944612,0.0002193389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006291613,0.0009289435,0.00008057791,0.005612601,0.0003369081,0.000002779046,0.001523445,2.670644e-7,0.0001300952,0.00061039,0.0004726876,0.9902384],"study_design_scores_gemma":[0.00324148,0.00002439265,0.003441912,0.006724868,0.004894665,0.00004554856,0.0003316548,0.000009206625,0.001142461,0.0004063147,0.9793484,0.0003890675],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08334523,0.913266,0.000004607537,0.0000747775,0.000813789,0.002068936,0.0001376991,0.00002593771,0.0002630163],"genre_scores_gemma":[0.01704999,0.9810278,0.0001197039,0.00004641483,0.001439209,0.00005761734,0.0001662793,0.00006114261,0.00003179262],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9898493,"threshold_uncertainty_score":0.9998548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07516644374966039,"score_gpt":0.4100552077642094,"score_spread":0.334888764014549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}