{"id":"W2201382378","doi":"10.1126/science.aad6780","title":"Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals","year":2015,"lang":"en","type":"article","venue":"Science","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1324,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"National Center for Advancing Translational Sciences; March of Dimes Foundation; National Institutes of Health; National Institute of Environmental Health Sciences; National Center for Chronic Disease Prevention and Health Promotion; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Biology; Offspring; Sperm; Biogenesis; Epigenetics; Phenotype; Transfer RNA; Genetics; Human fertilization; Metabolic pathway; Gene; Embryo; RNA; Andrology; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001788282,0.0001837373,0.0002101987,0.0003766038,0.0003239225,0.0003390153,0.000180214,0.0002794804,0.0006959063],"category_scores_gemma":[0.00018335,0.0001523462,0.0002139206,0.0001693234,0.000276875,0.0002498032,0.0002652338,0.0002074706,0.0003982662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774373,"about_ca_system_score_gemma":0.0001844563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000418285,"about_ca_topic_score_gemma":0.0007814483,"domain_scores_codex":[0.999882,0.00001851365,0.000009192198,0.00004963577,0.00002950986,0.00001105789],"domain_scores_gemma":[0.9998666,0.00001797009,0.00004867089,0.00001422479,0.00001954523,0.00003303873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006508022,0.00000461082,0.003078442,0.0000445387,0.000008938137,0.0001469505,0.00005791672,0.00004933052,0.9917618,0.0002993893,0.00002132333,0.004461572],"study_design_scores_gemma":[0.000009310415,0.000521242,0.2392052,0.00003240404,0.00005249628,0.002520961,0.0002014256,0.0008700073,0.7460018,0.0005364035,0.01002348,0.00002533606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757112,0.01196809,0.008776874,0.000111088,0.0000296472,0.00001192366,0.0004271608,0.0001355765,0.002828404],"genre_scores_gemma":[0.9903656,0.001957742,0.003869643,0.00003661394,0.00001097739,0.000008604931,0.0004303716,0.00003191156,0.003288475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006959063,"threshold_uncertainty_score":0.002328038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158932985232371,"score_gpt":0.2541297153107585,"score_spread":0.2382364167875214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}