{"id":"W2201580745","doi":"10.1021/acs.analchem.5b01019","title":"Sample-to-Answer Isolation and mRNA Profiling of Circulating Tumor Cells","year":2015,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; CMC Microsystems","keywords":"Circulating tumor cell; Prostate cancer; Liquid biopsy; Immunostaining; Gene expression profiling; Gene expression; Prostate; Computational biology; Chemistry; Whole blood; Cancer research; Gene; Cancer; Pathology; Biology; Internal medicine; Immunohistochemistry; Metastasis; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354063,0.0000792197,0.0002157107,0.00001998113,0.00001285629,0.000008231684,0.0000292807,0.00003990057,0.00008712871],"category_scores_gemma":[0.0002664304,0.00007111212,0.00005104721,0.0001324374,0.00003690248,0.00002266286,0.00003204414,0.00009272021,0.000003340646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004174155,"about_ca_system_score_gemma":0.000148485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006047718,"about_ca_topic_score_gemma":5.399769e-7,"domain_scores_codex":[0.9993066,0.000004682018,0.0002028974,0.0001758997,0.000180852,0.0001290222],"domain_scores_gemma":[0.9993507,0.00004376457,0.00004664264,0.0001491628,0.0001263463,0.000283355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391447,0.0001248915,0.02493205,0.0006614958,0.00007258538,0.00001792457,0.0001313163,0.00006307624,0.9689353,0.0001670292,0.0007836218,0.003971575],"study_design_scores_gemma":[0.0008787338,0.00007617395,0.0006951043,0.0001571724,0.0002927966,0.00004303543,0.0004012055,0.01048066,0.9823237,0.0002159151,0.004273355,0.000162143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818466,0.0001761108,0.002406718,0.0001847843,0.00003626305,0.000110905,0.00001631485,0.00001662388,0.01520572],"genre_scores_gemma":[0.9903048,0.000003733201,0.008981188,0.0002109972,0.0001523304,0.000002946139,0.00001612758,0.00001014599,0.0003176921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02423694,"threshold_uncertainty_score":0.2899868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03905315785491743,"score_gpt":0.3013130266504174,"score_spread":0.2622598687955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}