{"id":"W2201705599","doi":"10.1128/aac.01393-15","title":"Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D β-Lactamase of Acinetobacter baumannii","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Indian Institute of Technology Roorkee; Indian Council of Medical Research; Ontario Ministry of Economic Development and Innovation","keywords":"Active site; Carbapenem; Acinetobacter baumannii; Enzyme; Chemistry; Stereochemistry; Hydrolysis; Acinetobacter; Imipenem; Combinatorial chemistry; Biochemistry; Microbiology; Biology; Antibiotics; Bacteria; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008495731,0.0002291415,0.0003039211,0.0001349566,0.0001526323,0.0004074977,0.0002605534,0.0002387934,0.001092372],"category_scores_gemma":[0.0003593045,0.0002076648,0.0002602983,0.0001613232,0.0002526534,0.000195196,0.0002948964,0.0003974938,0.0002737279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003347417,"about_ca_system_score_gemma":0.0003056862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125358,"about_ca_topic_score_gemma":0.001052111,"domain_scores_codex":[0.9998535,0.00001861938,0.00001350823,0.00002800356,0.00004758372,0.00003888796],"domain_scores_gemma":[0.9998455,0.0000274237,0.00005350235,0.00001986761,0.00001597223,0.00003763237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002378548,0.00007419656,0.004317067,0.00006195855,0.00001772681,0.00045281,0.00005786601,0.0007086197,0.9909745,0.0002952499,0.00006121826,0.002741053],"study_design_scores_gemma":[0.0001459761,0.0005641198,0.08565161,0.00003527336,0.00007374956,0.002962958,0.0004342945,0.01003504,0.8937343,0.0006044698,0.005700811,0.00005748235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988288,0.0002222905,0.0003523308,0.0000327161,0.000004817008,0.000004118261,0.00005742582,0.00002115052,0.0004763512],"genre_scores_gemma":[0.9992934,0.00007060942,0.0003031649,0.00001166074,0.000001673306,0.00000480111,0.000148911,0.000007415887,0.0001582885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125358,"threshold_uncertainty_score":0.003654361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008283159568691746,"score_gpt":0.2426996305593264,"score_spread":0.2344164709906347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}