{"id":"W2201728328","doi":"10.1126/scisignal.aac5356","title":"Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17","year":2015,"lang":"en","type":"article","venue":"Science Signaling","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Medical Research Council; Canadian Institutes of Health Research; National Cancer Institute; Cancer Research UK; National Institutes of Health; Deutsche Forschungsgemeinschaft; Alexander von Humboldt-Stiftung; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Protease; Cytoplasm; Receptor; Cell biology; Biology; Tumor necrosis factor alpha; Tumor necrosis factor receptor; Cancer research; Molecular biology; Immunology; Enzyme; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540662,0.0003756858,0.0002288933,0.0002307151,0.0001520794,0.0002917375,0.000253302,0.0003108745,0.002265977],"category_scores_gemma":[0.0001525638,0.0002473333,0.000419365,0.0001473372,0.0002646193,0.0001911539,0.0003401898,0.0007723262,0.0007772371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143404,"about_ca_system_score_gemma":0.0001402187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000337287,"about_ca_topic_score_gemma":0.0004738006,"domain_scores_codex":[0.9997639,0.00003500943,0.00003607875,0.00004373087,0.00005350809,0.00006769955],"domain_scores_gemma":[0.9997751,0.0000434908,0.00007873125,0.0000422927,0.000007152319,0.00005314719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002528693,0.00008034219,0.000408053,0.00002890466,0.000007525826,0.0001961749,0.00001827558,0.00007316502,0.9980819,0.00006180174,0.00006486142,0.000726212],"study_design_scores_gemma":[0.00009062773,0.0008864049,0.01424074,0.00001245613,0.00002950454,0.001781027,0.00008454985,0.001322668,0.9781186,0.0000435205,0.003378424,0.00001149863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976118,0.0003294736,0.0005973229,0.00004613554,0.00002001169,0.00001849409,0.0002545911,0.00005879496,0.001063534],"genre_scores_gemma":[0.9965273,0.0002754324,0.0008311043,0.00003662572,0.000009037466,0.00002080381,0.0004971123,0.00002301814,0.001779571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002265977,"threshold_uncertainty_score":0.007580519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314808158978903,"score_gpt":0.2515754435725462,"score_spread":0.2384273619827572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}