{"id":"W2201728328","doi":"10.1126/scisignal.aac5356","title":"Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17","year":2015,"lang":"en","type":"article","venue":"Science Signaling","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Medical Research Council; Canadian Institutes of Health Research; National Cancer Institute; Cancer Research UK; National Institutes of Health; Deutsche Forschungsgemeinschaft; Alexander von Humboldt-Stiftung; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Protease; Cytoplasm; Receptor; Cell biology; Biology; Tumor necrosis factor alpha; Tumor necrosis factor receptor; Cancer research; Molecular biology; Immunology; Enzyme; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001676447,0.00007431113,0.00007546569,0.00002674713,0.0001894405,0.00003052252,0.000504055,0.00003801228,0.000003554852],"category_scores_gemma":[0.0002369543,0.00003654707,0.00003586998,0.0003483136,0.000648567,0.000009601879,0.0001255282,0.00009064304,4.425018e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001027904,"about_ca_system_score_gemma":0.0001962917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007100777,"about_ca_topic_score_gemma":0.00001989797,"domain_scores_codex":[0.9991089,0.0001006518,0.0001648058,0.0001948327,0.0002564698,0.0001744187],"domain_scores_gemma":[0.9994751,0.00001745869,0.000105333,0.0002792023,0.00008511446,0.00003784605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001141012,0.00002615521,0.0007853323,0.000006432744,0.000002383664,1.32296e-7,0.0007654807,0.00008033305,0.9971533,0.0001973231,0.0001658845,0.0008057845],"study_design_scores_gemma":[0.000260021,0.0001446862,0.0003560525,0.00005846551,0.000005108556,0.000008387354,0.002626075,0.0002196678,0.9928442,0.0006771921,0.002723134,0.00007697719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978146,0.0004436336,0.0003286015,0.0007414823,0.00004076002,0.0003982472,0.00001064015,0.000001927683,0.0002201196],"genre_scores_gemma":[0.999139,0.000009678556,0.0006235066,0.0001240328,0.00003499577,0.00002835756,0.000001929857,0.00000448395,0.00003405667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004309115,"threshold_uncertainty_score":0.2389672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314808158978903,"score_gpt":0.2515754435725462,"score_spread":0.2384273619827572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}