{"id":"W2201949943","doi":"10.1161/circheartfailure.115.002383","title":"Deletion of <i>capn4</i> Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation","year":2015,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Lawson Health Research Institute","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Proinflammatory cytokine; Mitochondrion; Mitochondrial ROS; SOD2; Reactive oxygen species; ATP synthase; Calpain; Calpastatin; Lipopolysaccharide; Knockout mouse; Downregulation and upregulation; Superoxide; Biology; Cell biology; Superoxide dismutase; Oxidative stress; Molecular biology; Chemistry; Inflammation; Endocrinology; Immunology; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004083908,0.0001438043,0.0001334123,0.00005091635,0.0002212925,0.00006109124,0.00004265538,0.0001879402,0.000005382455],"category_scores_gemma":[0.0002624714,0.0001260075,0.00007842432,0.0001286926,0.00009077799,0.00003174353,0.00004232798,0.0001121612,0.000003374568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003299032,"about_ca_system_score_gemma":0.00008626302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002857502,"about_ca_topic_score_gemma":0.00002280079,"domain_scores_codex":[0.9987285,0.0002219771,0.000337475,0.0003195493,0.0002344096,0.0001581414],"domain_scores_gemma":[0.999348,0.00001609957,0.0001492545,0.0002082502,0.0001898919,0.0000884871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005203214,0.00002838444,0.0019787,0.00002589853,0.00001173105,1.003099e-7,0.0001159539,0.0007955161,0.9896411,0.0000275894,0.00609816,0.001224788],"study_design_scores_gemma":[0.0009958493,0.0001547822,0.0009221057,0.00006795606,0.00002599997,0.00003611139,0.0002404627,0.007673891,0.9387195,0.00005524077,0.05087189,0.0002362897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879037,0.0003021357,0.009212801,0.001426927,0.0001831928,0.0009084422,0.00001603481,0.0000255784,0.00002120166],"genre_scores_gemma":[0.9975066,0.000007253821,0.000914429,0.0002584187,0.0006183215,0.00009375625,0.0005209847,0.00002104441,0.00005923866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05092172,"threshold_uncertainty_score":0.5138436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298523636992908,"score_gpt":0.2383222957252076,"score_spread":0.2253370593552785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}