{"id":"W2202470170","doi":"10.1182/blood.v124.21.5670.5670","title":"A Phase II Study of AT7519M, a CDK Inhibitor, in Patients with Chronic Lymphocytic Leukemia: NCIC CTG Trial IND.193","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Juravinski Cancer Centre; Kingston General Hospital; Princess Margaret Cancer Centre; CancerCare Manitoba; University of Toronto","funders":"","keywords":"Medicine; Tumor lysis syndrome; Internal medicine; Chronic lymphocytic leukemia; Regimen; Gastroenterology; Cytopenia; Febrile neutropenia; Oncology; Neutropenia; Leukemia; Immunology; Chemotherapy; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006901926,0.000371783,0.0009500421,0.0004558126,0.000103422,0.00002134294,0.0003153928,0.0002342129,0.00007626603],"category_scores_gemma":[0.0004577854,0.0002925056,0.0001113063,0.0008799921,0.0001800485,0.0001335787,0.0002743453,0.0004459723,0.00003992541],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03192512,"about_ca_system_score_gemma":0.02712504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00231768,"about_ca_topic_score_gemma":0.0006698669,"domain_scores_codex":[0.9960517,0.0002264822,0.000849939,0.0006879844,0.001424622,0.0007593281],"domain_scores_gemma":[0.9979572,0.000203182,0.0002572969,0.001045197,0.0002391644,0.0002979187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5653092,0.2852555,0.06255072,0.003959711,0.003810308,0.00182841,0.01899506,0.000734454,0.003953878,0.0001846184,0.001778782,0.05163937],"study_design_scores_gemma":[0.9108613,0.08005922,0.002941716,0.0004202121,0.0004328839,0.00003278031,0.00015434,0.002141878,0.002456522,0.00001305025,0.0001994095,0.0002866704],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953993,0.0001588528,0.00000676755,0.00001279879,0.0001573475,0.00362729,0.00000834997,0.0000697483,0.000559519],"genre_scores_gemma":[0.9988465,0.000008881058,0.00005855007,0.00004691358,0.000462713,0.0002282659,0.00003438475,0.00007678384,0.0002370133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3455521,"threshold_uncertainty_score":0.9999527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125148004423638,"score_gpt":0.2805970150934022,"score_spread":0.2680822146510384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}