{"id":"W2202693501","doi":"10.48550/arxiv.1506.01731","title":"Predictable patterns of CTL escape and reversion across host populations and viral subtypes in HIV-1 evolution","year":2015,"lang":"en","type":"preprint","venue":"arXiv (Cornell University)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Reversion; CTL*; Biology; Population; Host (biology); Genetic Fitness; Viral evolution; Mutation; Genetics; Point mutation; Virus; Virology; Immune escape; Viral replication; Cytotoxic T cell; Immune system; Phenotype; Biological evolution; RNA; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059707,0.0001739252,0.0002639762,0.0005845429,0.0003917313,0.0006122129,0.0002691023,0.0003208717,0.0005215006],"category_scores_gemma":[0.002044817,0.0001827091,0.0002370539,0.0003423633,0.000539404,0.0003015231,0.0004131666,0.0003278392,0.0001287207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003805591,"about_ca_system_score_gemma":0.0002526948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002752539,"about_ca_topic_score_gemma":0.005240701,"domain_scores_codex":[0.9996238,0.00009185728,0.00002132466,0.0001277504,0.00007563177,0.00005956878],"domain_scores_gemma":[0.9988534,0.0004295103,0.0002734509,0.000206408,0.0001634928,0.00007359908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003047174,0.00006994211,0.834192,0.00004148982,0.0001650081,0.0001405197,0.001255432,0.002711142,0.1421897,0.0004601617,0.0001010761,0.0183689],"study_design_scores_gemma":[0.00000412566,0.0001332238,0.9920764,0.000003713708,0.00002806837,0.000198191,0.0003365792,0.002380761,0.004397019,0.0002250505,0.0002029909,0.00001385395],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992939,0.00006625045,0.0004171059,0.000006601801,6.906988e-7,0.000004097526,0.00004193626,0.000005744667,0.0001636423],"genre_scores_gemma":[0.9993488,0.00003814084,0.0004003172,0.000007586184,9.430715e-7,0.000006081827,0.0001115011,0.00000475712,0.00008188026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002752539,"threshold_uncertainty_score":0.005604327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05433848669047619,"score_gpt":0.2224964062046777,"score_spread":0.1681579195142015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}