{"id":"W2202780397","doi":"10.1016/j.brainres.2015.12.032","title":"Microparticles generated during chronic cerebral ischemia increase the permeability of microvascular endothelial barriers in vitro","year":2015,"lang":"en","type":"article","venue":"Brain Research","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"RHOA; Tumor necrosis factor alpha; Pharmacology; Apoptosis; Ischemia; In vitro; Blood–brain barrier; Transcellular; Western blot; Vascular endothelial growth factor; Chemistry; Signal transduction; Medicine; Biology; Cancer research; Cell biology; Immunology; Endocrinology; Internal medicine; Biochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000253445,0.0003062334,0.0003861569,0.0002183819,0.0001626052,0.0003985972,0.0001596231,0.000379448,0.0008732853],"category_scores_gemma":[0.000267366,0.0001309806,0.000324763,0.0002012589,0.0002202839,0.0005210954,0.0001614266,0.0006230584,0.0001807047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788502,"about_ca_system_score_gemma":0.0001859119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007744624,"about_ca_topic_score_gemma":0.0006918698,"domain_scores_codex":[0.9998833,0.00001707466,0.00001042369,0.00001646372,0.00002721571,0.00004555218],"domain_scores_gemma":[0.9997899,0.0000791525,0.00004821429,0.00002113063,0.00003046593,0.00003103419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000822188,0.0001191154,0.000197235,0.0001072655,0.00001923102,0.000119727,0.00007846723,0.0000482727,0.996624,0.0001252214,0.0001018056,0.001637566],"study_design_scores_gemma":[0.00005881855,0.001329732,0.005322598,0.00001232026,0.00005928066,0.0002402906,0.00005449397,0.0003961531,0.9915799,0.00007457611,0.0008649611,0.000006805282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948502,0.002710445,0.001793136,0.00006616546,0.00004759469,0.00001379602,0.000102172,0.0000216139,0.0003949264],"genre_scores_gemma":[0.9970241,0.001072641,0.0008339214,0.00004130971,0.00003460996,0.00002130522,0.0001926923,0.000008613176,0.0007708126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008732853,"threshold_uncertainty_score":0.002921462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06981134038209819,"score_gpt":0.32969133759721,"score_spread":0.2598799972151118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}