{"id":"W2203142821","doi":"10.1158/1078-0432.ccr-15-0124","title":"Failures in Phase III: Causes and Consequences","year":2015,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Clinical trial; Randomized controlled trial; Drug development; Phases of clinical research; Population; Intensive care medicine; Cancer; Oncology; Pharmacology; Internal medicine; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2376348,0.001742955,0.005326538,0.002397139,0.001151398,0.00352379,0.003871487,0.004051347,0.008011115],"category_scores_gemma":[0.2965803,0.001449142,0.006407878,0.004536293,0.006787505,0.004941353,0.003660131,0.006987607,0.00231486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004591453,"about_ca_system_score_gemma":0.009437007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001645497,"about_ca_topic_score_gemma":0.002025257,"domain_scores_codex":[0.8083987,0.1267795,0.02998751,0.007902849,0.02543141,0.001500093],"domain_scores_gemma":[0.4747365,0.4490582,0.04194373,0.01720178,0.01494287,0.00211693],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002204071,0.0002374577,0.005566278,0.07212984,0.004730847,0.0005922385,0.001098868,0.002644732,0.0005149657,0.09066025,0.04435145,0.775269],"study_design_scores_gemma":[0.004128172,0.002866423,0.01089938,0.1102372,0.007614269,0.005580188,0.001000872,0.004889579,0.003240124,0.3133964,0.5358744,0.0002728988],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004628147,0.9089777,0.04165613,0.02744186,0.003111832,0.003004252,0.0008832806,0.0002540221,0.01004271],"genre_scores_gemma":[0.1609282,0.6830961,0.06456207,0.06737822,0.005468837,0.01184233,0.001113174,0.0006373257,0.004973811],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7623652,"threshold_uncertainty_score":0.940132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9760698571292453,"score_gpt":0.8318534788750754,"score_spread":0.1442163782541699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}