{"id":"W2203561322","doi":"10.1093/hmg/ddv513","title":"AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Computer Research Institute of Montréal","funders":"Agence Nationale de la Recherche; CHDI Foundation; Hereditary Disease Foundation","keywords":"AMPK; Biology; Huntingtin; Protein kinase A; AMP-activated protein kinase; Huntington's disease; Neurodegeneration; Autophagy; Cell biology; Internal medicine; Kinase; Genetics; Disease; Medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001370872,0.0002572931,0.000223253,0.00005686317,0.0001904139,0.0001076316,0.0001688911,0.00006644574,0.000005248054],"category_scores_gemma":[0.0004188409,0.0002747938,0.00005330947,0.0001328834,0.0003333379,0.0001361445,0.0002535223,0.0001472584,0.000001827503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002088307,"about_ca_system_score_gemma":0.00007080143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004029583,"about_ca_topic_score_gemma":0.000005845004,"domain_scores_codex":[0.9977569,0.0003781293,0.0003131115,0.0007670245,0.0005062722,0.0002785645],"domain_scores_gemma":[0.9987477,0.00005805993,0.0001845527,0.0004971829,0.0001533373,0.000359144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007580058,0.0001331916,0.00167986,0.00004818892,0.000005276753,0.000004186551,0.0003498061,0.009166924,0.9877418,0.000542354,0.00001574381,0.0002368916],"study_design_scores_gemma":[0.0007803058,0.0001434528,0.01981566,0.00001409651,0.00003044518,4.994219e-7,0.00005558006,0.01107683,0.9599166,0.007920722,0.00001647955,0.0002293083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837241,0.0001449614,0.01520967,0.00005067672,0.00005558956,0.0006386019,0.00007697911,0.00006206698,0.00003732763],"genre_scores_gemma":[0.9990758,0.00001631341,0.0004922068,0.000234608,0.00003987838,0.00004701784,0.00002527205,0.00004686285,0.00002201144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02782516,"threshold_uncertainty_score":0.9999704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05098715551078774,"score_gpt":0.2818281098524395,"score_spread":0.2308409543416517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}