{"id":"W2203779828","doi":"","title":"Abstract 16333: PI3Kα Has a Role in Myocardial Insulin Signaling and Recovery From Cre/Tamoxifen Cardiotoxicity, but is not Required for Normal Function in the Adult Mouse Heart","year":2014,"lang":"en","type":"article","venue":"","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Tamoxifen; Medicine; PI3K/AKT/mTOR pathway; Endocrinology; Cardiotoxicity; Contractility; Internal medicine; Heart failure; Protein kinase B; Cardiac function curve; Genetically modified mouse; Heart disease; Insulin; Transgene; Breast cancer; Toxicity; Signal transduction; Cancer; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002975443,0.0009128372,0.0005621318,0.0007688774,0.0004452876,0.0004818224,0.000502523,0.001026672,0.01940777],"category_scores_gemma":[0.0001512998,0.0004325076,0.0005449454,0.0004972884,0.0005039306,0.000543652,0.0002968832,0.00210831,0.006456646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005720322,"about_ca_system_score_gemma":0.0005409136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001033386,"about_ca_topic_score_gemma":0.001217675,"domain_scores_codex":[0.9996129,0.00003116289,0.00004749711,0.00009451353,0.000130382,0.00008353192],"domain_scores_gemma":[0.9996716,0.00002371673,0.0001086544,0.00003999782,0.00003385134,0.0001222353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004960576,0.00007050373,0.0001575566,0.00009573723,0.000008701205,0.0001496474,0.0000229937,0.00003093262,0.9956627,0.0002832888,0.0006148223,0.002407126],"study_design_scores_gemma":[0.0002843447,0.0008357271,0.009307845,0.00007385268,0.00005210024,0.001562538,0.00007128822,0.0006473541,0.9587355,0.0002310408,0.02818132,0.00001707958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9125533,0.008405891,0.02632758,0.003456746,0.00106842,0.0004283859,0.02012195,0.002751978,0.02488582],"genre_scores_gemma":[0.8269196,0.006033773,0.01544702,0.001026347,0.0002153503,0.0007558651,0.02286739,0.000843685,0.125891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01940777,"threshold_uncertainty_score":0.06492549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239516853921899,"score_gpt":0.2409355543808812,"score_spread":0.2185403858416622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}